Shaanxi Provincial Key Laboratory of Papermaking Technology and Specialty Paper Development, Shaanxi University of Science and Technology, Xi'an 710021, China.
Shaanxi Provincial Key Laboratory of Papermaking Technology and Specialty Paper Development, Shaanxi University of Science and Technology, Xi'an 710021, China.
Carbohydr Polym. 2024 Mar 15;328:121707. doi: 10.1016/j.carbpol.2023.121707. Epub 2023 Dec 18.
In this study, the quaternized carboxymethyl chitosan (QCMCS), oxidized hyaluronic acid (OHA), 3,3'-dithiobis-(propionohydrazide) (DTP) were used as raw materials for the synthesis of hydrogels with excellent properties as carriers for drug release. The hydrogels were prepared by a simple "one-pot" method without external stimuli on the basis of interactions between formed dynamic covalent bonds (imine bonds, acylhydrazone bonds, disulfide bonds) and hydrogen bonds. The hydrogels had rapid self-healing properties, with a self-healing rate of 96 % after 30 min, as well as good pH responsiveness and excellent cytocompatibility (up to 98 % cell survival). The compressive stress of the hydrogels reached 423 kPa. Moreover, a representative drug (acetylsalicylic acid) demonstrated sustained release in the hydrogels (>72 h). The drug release behaviour was shown to be consistent with the Fick diffusion mechanism by kinetic modelling. Collectively, the findings demonstrate that the QCMCS + OHA + DTP injectable self-healing hydrogels are a potential material for the construction of pH-controlled drug delivery platforms.
在这项研究中，季铵化羧甲基壳聚糖（QCMCS）、氧化透明质酸（OHA）、3,3'-二硫代双（丙酰腙）（DTP）被用作合成水凝胶的原料，这些水凝胶具有优异的性能，可作为药物释放的载体。水凝胶是通过一种简单的“一锅法”制备的，无需外部刺激，其基础是形成的动态共价键（亚胺键、酰腙键、二硫键）和氢键之间的相互作用。水凝胶具有快速的自修复性能，30 分钟后自修复率达到 96%，具有良好的 pH 响应性和优异的细胞相容性（细胞存活率高达 98%）。水凝胶的压缩应力达到 423kPa。此外，一种代表性药物（乙酰水杨酸）在水凝胶中表现出持续释放（超过 72 小时）。通过动力学建模，药物释放行为显示符合菲克扩散机制。总的来说，这些发现表明，QCMCS+OHA+DTP 可注射自修复水凝胶是构建 pH 控制药物输送平台的一种有潜力的材料。
