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[1976 - 1985年期间40万居民中原发性肾小球疾病的年发病率变化过程]

[Course of the annual incidence of primary glomerulopathies in a population of 400,000 inhabitants over a 10-year period (1976-1985)].

作者信息

Simon P, Ramee M P, Ang K S, Cam G

出版信息

Nephrologie. 1986;7(5):185-9.

PMID:3822040
Abstract

Between January 1976 and December 1985, renal biopsy was indicated in 663 adults (greater than 15 yrs) patients who were born and lived in a rural area of 400,000 inhabitants. Annual incidence (AI) was 16.5/100,000. Primary GN was diagnosed in 418 pts (63%) corresponding to a prevalence (P) for 10 yrs of 1/1000. The results have been compared for two periods: A (1976-1980) and B (1981-1985) for which the number of patients with primary GN was similar (205 vs 213, AI: 10.3 vs 10.6/100,000). Sex-ratio M/F (2.1 vs 1.8) and mean age (+/- SD) at the time of renal biopsy (45 +/- 17) were not different. P (%) among primary GN, P (nb/1000) among global population, AI (nb/100,000) and sex-ratio (A vs B) were evaluated for each histological type: lipoid nephrosis (MC and HSF): 9.8%, 0.1/1000, 1.2 vs 0.8/100,000 (ns), 1 vs 1.5 (ns). Membranous nephropathy 12.4%, 0.13/1000, 1.1 vs 1.5/100,000 (ns), 1.75 vs 0.8 (less than 0.02). IgAGN (Berger): 27%, 0.28/1000, 2.6 vs 3/100,000 (ns), 3 vs 3.3 (ns). IgAGN (Schönlein-Henoch): 5%, 0.05/1000, 0.45 vs 0.6/100,000 (ns), 3 vs 5 (ns). MPGN: 5.9%, 0.06/1000, 1 vs 0.25/100,000 (less than 0.01), 2.3 vs 1.5 (ns). Post streptococcal AGN: 2.8%, 0.03/1000, 0.55 vs 0.05/100,000 (less than 0.01). Non post-streptococcal AGN: 6.7%, 0.07/1000, 0.65 vs 0.75/100,000 (ns), 1.2 vs 0.6. Idiopathic crescentic GN: 4.7%, 0.05/1000, 0.25 vs 0.75/100,000 (less than 0.01) 1.5 vs 1.5. S and F proliferative GN: 1.9%, 0.02/1000, 0.15 vs 0.25/100,000 (ns), 2 vs 0.2.(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

1976年1月至1985年12月期间,对出生并居住在一个有40万居民的农村地区的663名成年人(年龄大于15岁)进行了肾活检。年发病率(AI)为16.5/10万。418例患者(63%)被诊断为原发性肾小球肾炎(GN),10年患病率(P)为1/1000。对两个时期的结果进行了比较:A期(1976 - 1980年)和B期(1981 - 1985年),这两个时期原发性GN患者数量相似(205例对213例,AI:10.3对10.6/10万)。肾活检时的性别比M/F(2.1对1.8)和平均年龄(±标准差)(45±17)无差异。对每种组织学类型评估了原发性GN中的P(%)、全球人群中的P(例数/1000)、AI(例数/10万)和性别比(A期对B期):脂性肾病(微小病变和局灶节段性硬化):9.8%,0.1/1000,1.2对0.8/10万(无显著性差异),1对1.5(无显著性差异)。膜性肾病12.4%,0.13/1000,1.1对1.5/10万(无显著性差异),1.75对0.8(小于0.02)。IgA肾病(伯杰病):27%,0.28/1000,2.6对3/10万(无显著性差异),3对3.3(无显著性差异)。IgA肾病(过敏性紫癜性肾炎):5%,0.05/1000,0.45对0.6/10万(无显著性差异),3对5(无显著性差异)。膜增生性肾小球肾炎:5.9%,0.06/1000,1对0.25/10万(小于0.01),2.3对1.5(无显著性差异)。链球菌感染后肾小球肾炎:2.8%,0.03/1000,0.55对0.05/10万(小于0.01)。非链球菌感染后肾小球肾炎:6.7%,0.07/1000,0.65对0.75/10万(无显著性差异),1.2对0.6。特发性新月体性肾小球肾炎:4.7%,0.05/1000,0.25对0.75/10万(小于0.01),1.5对1.5。系膜增生性和局灶节段增生性肾小球肾炎:1.9%,0.02/1000,0.15对0.25/10万(无显著性差异),2对0.2。(摘要截断于250字)

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