Habes Yousef Mahmoud Nimer, Ahmaro Manar, Dwikat Yasmin, Jobran Afnan W M, Abunejma Fawzy Mazen, Abdulrazzak Mohammed
Faculty of Medicine, Al Quds University, Jerusalem.
Internal Medicine, Istishari Arab Hospital, Ramallah.
Ann Med Surg (Lond). 2023 Nov 16;86(1):517-521. doi: 10.1097/MS9.0000000000001502. eCollection 2024 Jan.
SLE, or systemic lupus erythematosus, is a chronic autoimmune condition of uncertain origin characterized by the presence of autoantibodies that target the body's own antigens.
A 16-year-old female presented at the emergency room with a right-sided lip droop and subsequently developed symptoms consistent with a malignant hemispheric infarction, including altered consciousness, hemiplegia, and forced gaze deviation. Her laboratory results were within the normal range. However, a brain MRI revealed cerebral edema and a massive infarction in the middle cerebral artery (MCA) region. Subsequently, her serologic profile was indicative of SLE, leading to a later diagnosis.
The patient in this case presented with symptoms suggestive of a stroke. A CT scan showed MCA occlusion, leading to a diagnosis of malignant MCA syndrome. The patient was also diagnosed with systemic lupus erythematosus, which is associated with an increased risk of stroke. Inflammation-induced thrombosis and CNS vasculitis are potential mechanisms linking SLE and stroke.
This case serves as an example of a sudden and potentially life-threatening presentation of SLE, underscoring the importance of early detection and targeted treatment that can influence the course of the disease.
系统性红斑狼疮（SLE）是一种起源不明的慢性自身免疫性疾病，其特征是存在针对机体自身抗原的自身抗体。
一名16岁女性因右侧嘴角下垂就诊于急诊室，随后出现与恶性半球梗死相符的症状，包括意识改变、偏瘫和凝视偏斜。她的实验室检查结果在正常范围内。然而，脑部MRI显示脑水肿和大脑中动脉（MCA）区域的大面积梗死。随后，她的血清学检查结果提示为系统性红斑狼疮，最终得以确诊。
该病例中的患者表现出提示中风的症状。CT扫描显示MCA闭塞，导致诊断为恶性MCA综合征。该患者还被诊断为系统性红斑狼疮，其与中风风险增加有关。炎症诱导的血栓形成和中枢神经系统血管炎是将系统性红斑狼疮与中风联系起来的潜在机制。
该病例是系统性红斑狼疮突然发作且可能危及生命的一个实例，强调了早期检测和针对性治疗的重要性，这可能会影响疾病的进程。
