Lee Byung-Jou, Seok Min Cheol, Koo Hae-Won, Jeong Je Hoon, Ko Myeong Jin
Department of Neurosurgery, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.
Department of Neurosurgery, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.
Korean J Neurotrauma. 2023 Dec 19;19(4):446-453. doi: 10.13004/kjnt.2023.19.e62. eCollection 2023 Dec.
Spinal trauma accounts for a large portion of injuries to the spine area, particularly as societies are entering an era of aging populations. Consequently, spine fractures accompanied by osteoporosis are becoming more prevalent. Achieving successful fusion surgery in patients with spine fractures associated with osteoporosis is even more challenging. Pseudarthrosis in the spine does not yield clinically favorable results; however, considerable effort has been made to achieve successful fusion, and the advancement of bone graft substitutes has been particularly crucial in this regard. Autograft bone is considered the best fusion material but is limited in use due to the quantity that can be harvested during surgery and associated complications. Accordingly, various bone graft substitutes are currently being used, although no specific guidelines are available and this mainly depends on the surgeon's choice. Therefore, the purpose of this review, across part I/II, is to summarize bone graft substitutes commonly used in spine surgery for spine fusion in patients with spine trauma and to update the latest knowledge on the role of recombinant human bone morphogenetic protein-2.
脊柱创伤在脊柱区域损伤中占很大比例，尤其是随着社会步入老龄化时代。因此，伴有骨质疏松症的脊柱骨折正变得越来越普遍。在患有与骨质疏松症相关的脊柱骨折的患者中实现成功的融合手术更具挑战性。脊柱假关节不会产生临床上有利的结果；然而，为实现成功融合已付出了相当大的努力，并且骨移植替代物的进展在这方面尤为关键。自体骨被认为是最佳的融合材料，但由于手术中可获取的数量以及相关并发症，其使用受到限制。因此，目前正在使用各种骨移植替代物，尽管没有具体的指导方针，这主要取决于外科医生的选择。因此，本综述在第一部分/第二部分的目的是总结脊柱手术中常用于脊柱创伤患者脊柱融合的骨移植替代物，并更新关于重组人骨形态发生蛋白-2作用的最新知识。
