Department of Traditional Chinese Medicine, Children's Hospital Affiliated to Medical College of Zhejiang University, Hangzhou 310057, Zhejiang Province, China.
School of Basic Medical Sciences, Zhejiang Chinese Medical University, Zhejiang Hangzhou, 310053, China.
Afr Health Sci. 2023 Jun;23(2):709-714. doi: 10.4314/ahs.v23i2.81.
The clinical efficacy of "Lanzhou prescription" plus or minus combined with western medicine in the treatment of children with acute aplastic anemia, 'excessive accumulation of heat toxin', was comprehensively and objectively evaluated.
Sixty children diagnosed with acute aplastic anemia, 'excessive accumulation of heat toxin' were divided into observation group (lanzhou prescription plus or minus combined with immunosuppressive therapy) and control group (immunosuppressive therapy alone). The relief degree of clinical symptoms and signs and the change of laboratory indicators were taken as the evaluation criteria.
(1) After treatment, the results of remission rate of two groups treated by western medicine shows that the remission rate of the observation group was significantly higher than the control group (P< 0.05). (2) the 'cure rate' of the observation group treated for 6 months was significantly higher than treated for 3 months (P<0.05). (3) After treated for 6 months, the indexes of CD34+ cells and FOXP3+ regulatory cells in bone marrow of observation group increased, while the CD8+ cells and B cells decreased significantly, and the indexes of CD3+ cells, CD4+ cells and NK cells decreased somewhat(P<0.05).
Compared with immunosuppressive therapy, lanzhou prescription plus or minus combined with immunosuppressive therapy can alleviate the clinical symptoms and signs of children more effectively, obviously improve the Traditional Chinese Medicine symptoms of children, and help bone marrow hematopoietic stem cells gradually restore hematopoietic function.
全面客观地评价“兰州方”加减联合西药治疗儿童急性再生障碍性贫血“热毒炽盛证”的临床疗效。
将 60 例急性再生障碍性贫血“热毒炽盛证”患儿分为观察组（兰州方加减联合免疫抑制治疗）和对照组（单纯免疫抑制治疗），以临床症状体征缓解程度及实验室指标变化为评价标准。
（1）两组患儿经西药治疗后缓解率结果显示，观察组缓解率明显高于对照组（P<0.05）。（2）观察组治疗 6 个月的“治愈率”明显高于治疗 3 个月（P<0.05）。（3）观察组治疗 6 个月后骨髓 CD34+细胞、FOXP3+调节性 T 细胞的指标升高，CD8+细胞、B 细胞明显降低，CD3+细胞、CD4+细胞、NK 细胞的指标略有下降（P<0.05）。
与免疫抑制治疗相比，兰州方加减联合免疫抑制治疗可更有效地缓解患儿的临床症状和体征，明显改善患儿的中医证候，有助于骨髓造血干细胞逐渐恢复造血功能。
