Kundu Anita, Thomas Akshay S, Mirzania Delaram, Kim Jane S, Stinnett Sandra S, Fekrat Sharon
Department of Ophthalmology, Duke University School of Medicine, Durham, NC, USA.
Tennessee Retina, Nashville, TN, USA.
J Vitreoretin Dis. 2023 Nov 10;8(1):51-57. doi: 10.1177/24741264231205378. eCollection 2024 Jan-Feb.
To compare the risk factors and clinical outcomes in patients younger than 50 years with acute, treatment-naïve branch retinal vein occlusion (BRVO) with outcomes in patients 50 years or older. Patients diagnosed with acute, treatment-naïve BRVO at Duke Eye Center over a 9.5-year period who had BRVO with onset 3 months or less before presentation, BRVO with macular involvement, and 12 months or more of follow-up were included. Demographic data, presenting clinical features, risk factors, treatment patterns, and clinical outcomes were extracted during a retrospective review of medical records. Of 302 patients identified, 23 were younger than 50 years (younger group) and 279 were 50 years or older (older group). Compared with older patients, younger patients had similar rates of hypertension ( = .275), diabetes mellitus ( = 1.000), smokers ( = .787), and open-angle glaucoma ( = .628). The younger group had a lower rate of hyperlipidemia than the older group (35% vs 59%) ( = .028). The 2 groups had similar presenting logMAR visual acuities (VAs) in the BRVO eye ( = .131). At the final follow-up, younger patients had significantly better logMAR VA in the BRVO-affected eye than older patients (mean 0.51 ± 0.65 vs 1.01 ± 1.20) ( = .016). The 2 groups had similar treatment burdens at 1 year ( = .516) and at the final follow-up ( = .782). Younger patients with acute, treatment-naïve BRVO have similar risk factors and treatment patterns as older patients, except for a lower rate of hyperlipidemia. Younger patients with BRVO may have similar presenting VA as older BRVO patients but better final VA, suggesting that age may be a potential prognostic factor.
比较50岁以下初发急性视网膜分支静脉阻塞（BRVO）患者与50岁及以上患者的危险因素和临床结局。纳入在杜克眼科中心9.5年期间诊断为初发急性BRVO的患者，这些患者在就诊前3个月或更短时间内发病，伴有黄斑受累的BRVO，且随访时间为12个月或更长。在对病历进行回顾性审查期间提取人口统计学数据、就诊时的临床特征、危险因素、治疗模式和临床结局。在302例确诊患者中，23例年龄小于50岁（较年轻组），279例年龄在50岁及以上（较年长组）。与年长患者相比，年轻患者的高血压（P = 0.275）、糖尿病（P = 1.000）、吸烟者（P = 0.787）和开角型青光眼（P = 0.628）发生率相似。较年轻组的高脂血症发生率低于较年长组（35%对59%）（P = 0.028）。两组在BRVO眼的就诊时logMAR视力（VA）相似（P = 0.131）。在最后一次随访时，较年轻患者BRVO受累眼的logMAR VA明显优于较年长患者（平均0.51±0.65对1.01±1.20）（P = 0.016）。两组在1年时（P = 0.516）和最后一次随访时（P = 0.782）的治疗负担相似。初发急性BRVO的年轻患者除高脂血症发生率较低外，其危险因素和治疗模式与年长患者相似。BRVO年轻患者的就诊时VA可能与年长BRVO患者相似，但最终VA更好，这表明年龄可能是一个潜在的预后因素。
