Eye Center, Second Affiliated Hospital, School of Medicine, Zhejiang University, No.88, Jiefang Road, 310009, Hangzhou, China.
The Institute of Translational Medicine, Zhejiang University, Hangzhou, China.
BMC Ophthalmol. 2021 Apr 5;21(1):161. doi: 10.1186/s12886-021-01931-5.
To compare changes in retinal microvasculature of young and elderly patients with retinal vein occlusion (RVO) after anti-VEGF treatment.
RVO patients who underwent anti-VEGF treatment were retrospectively reviewed and categorized into two groups based on age. The OCT angiography images were obtained during each visit. Best corrected visual acuity (BCVA), vessel density (VD) and foveal avascular zone (FAZ) were measured and compared between the two groups. Vision improvements and retinal microvasculature changes were also correlated.
Twenty patients with 20 eyes were enrolled in the younger group and 46 patients with 46 eyes were enrolled in the older group. Younger patients demonstrated better BCVA, higher VD and smaller FAZ than older patients at 12 months after the first anti-VEGF treatment. The improvement of VD was observed only in the younger group. A positive correlation between vision improvement and VD increase was noted.
Young patients with RVO can achieve rapid rehabilitation of deep retinal vasculature which lead to a better visual outcome.
比较抗血管内皮生长因子（VEGF）治疗后年轻和老年视网膜静脉阻塞（RVO）患者视网膜微血管的变化。
回顾性分析接受抗 VEGF 治疗的 RVO 患者，并根据年龄分为两组。每次就诊时均获取 OCT 血管造影图像。测量两组最佳矫正视力（BCVA）、血管密度（VD）和中心凹无血管区（FAZ），并进行比较。还分析了视力改善与视网膜微血管变化之间的相关性。
年轻组纳入 20 例 20 眼，老年组纳入 46 例 46 眼。首次抗 VEGF 治疗后 12 个月，年轻组患者的 BCVA 更好，VD 更高，FAZ 更小。仅在年轻组观察到 VD 的改善。视力改善与 VD 增加呈正相关。
年轻的 RVO 患者可以快速恢复深层视网膜血管，从而获得更好的视力结果。
