Department of Neurology, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China.
Department of Cardiovascular Surgery ICU, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230001, China.
Diabetes Res Clin Pract. 2024 Feb;208:111094. doi: 10.1016/j.diabres.2024.111094. Epub 2024 Jan 13.
This Mendelian randomization (MR) study aimed to investigate the relationships between type 1 diabetes (T1D), type 2 diabetes (T2D), and glycemic traits, including fasting insulin, fasting glucose, and HbA1c, with cardiovascular diseases (CVDs).
We selected genetic instruments for predisposition to T1D, T2D, fasting insulin, fasting glucose, and HbA1c based on published genome-wide association studies. Using a 2-Sample MR approach, we assessed associations with 12 common CVDs sourced from the FinnGen and UK Biobank studies, along with stroke subtypes obtained from the GIGASTROKE and MEGASTROKE Consortium.
T1D was associated with SVS. T2D showed associations with AIS, LAA, CES, SVS, coronary heart disease, myocardial infarction, pulmonary embolism, DVT of lower extremities, peripheral vascular diseases. Genetically predicted higher HbA1c levels were associated with eight CVDs. The results of MVMR aligned with the primary findings for T1D and T2D.
T1D and T2D exhibit different genetic predisposition to CVDs. BMI, LDL, and HDL play intermediary roles in connecting TID and T2D to specific types of CVDs, providing insights into the potential underlying pathways and mechanisms involved in these relationships. Strategies aimed at achieving sustained reductions in HbA1c levels may offer potential for reducing the risk of various CVDs.
本孟德尔随机化（MR）研究旨在探讨 1 型糖尿病（T1D）、2 型糖尿病（T2D）和血糖特征（包括空腹胰岛素、空腹血糖和 HbA1c）与心血管疾病（CVD）之间的关系。
我们根据已发表的全基因组关联研究，选择了易患 T1D、T2D、空腹胰岛素、空腹血糖和 HbA1c 的遗传工具。使用两样本 MR 方法，我们评估了来自 FinnGen 和 UK Biobank 研究的 12 种常见 CVD 以及 GIGASTROKE 和 MEGASTROKE 联盟获得的中风亚型与这些遗传工具之间的关联。
T1D 与 SVS 相关。T2D 与 AIS、LAA、CES、SVS、冠心病、心肌梗死、肺栓塞、下肢深静脉血栓形成、外周血管疾病相关。遗传预测的 HbA1c 水平升高与 8 种 CVD 相关。MVMR 的结果与 T1D 和 T2D 的主要发现一致。
T1D 和 T2D 对 CVD 的遗传易感性不同。BMI、LDL 和 HDL 在连接 TID 和 T2D 与特定类型的 CVD 方面发挥中介作用，为这些关系中涉及的潜在潜在途径和机制提供了深入了解。旨在实现 HbA1c 水平持续降低的策略可能为降低各种 CVD 的风险提供了潜力。
