Kzar Al-Shukri Hamzah H, Abdul-Jabbar Ali Sana, Al-Akkam Karam Akram, Hjazi Ahmed, Rasulova Irodakhon, Mustafa Yasser Fakri, Al-Saidi Dahlia N, Alasheqi Mohammed Qasim, Alawadi Ahmed, Alsaalamy Ali
Department of Biochemistry, College of Veterinary Medicine, Al-Qasim Green University, Babylon, Iraq.
Pharmacy Department, Al Safwa University College, Karbalaa, Iraq.
Cell Biol Int. 2024 Mar;48(3):280-289. doi: 10.1002/cbin.12122. Epub 2024 Jan 15.
Small extracellular (EV) particles known as exosomes are released by a variety of cell types, including immune system cells, stem cells, and tumor cells. They are regarded as a subgroup of EVs and have a diameter that ranges from 30 to 150 nm. Proteins, lipids, nucleic acids (including RNA and DNA), and different bioactive compounds are among the wide range of biomolecules that make up the cargo of exosomes. Exosomes are crucial for intercellular communication because they let cells share information and signaling chemicals. They are involved in various physiological and pathological processes, including immune responses, tissue regeneration, cancer progression, and neurodegenerative diseases. In conclusion, it is essential to continue research into exosome-based cancer medicines to advance understanding, improve treatment plans, create personalized tactics, ensure safety, and speed up clinical translation.
被称为外泌体的细胞外小颗粒由多种细胞类型释放，包括免疫系统细胞、干细胞和肿瘤细胞。它们被视为细胞外囊泡的一个亚组，直径范围为30至150纳米。蛋白质、脂质、核酸（包括RNA和DNA）以及不同的生物活性化合物是构成外泌体货物的广泛生物分子中的一部分。外泌体对于细胞间通讯至关重要，因为它们使细胞能够共享信息和信号化学物质。它们参与各种生理和病理过程，包括免疫反应、组织再生、癌症进展和神经退行性疾病。总之，继续研究基于外泌体的癌症药物对于增进理解、改进治疗方案、制定个性化策略、确保安全性以及加速临床转化至关重要。
