Reed Kenneth Bryant, Pruitt Erin, Hansa Raj K C, Sharma Amit Raj, Medina-Bolivar Fabricio, Shields Robert Colquhoun
Department of Biological Sciences, Arkansas State University, Jonesboro, Arkansas, USA.
Department of Chemistry and Physics, Arkansas State University, Jonesboro, Arkansas, USA.
Nat Prod Res. 2025 Mar;39(6):1548-1556. doi: 10.1080/14786419.2024.2302316. Epub 2024 Jan 15.
In this study we evaluated the effect of prenylated peanut stilbenoids on the growth, biofilm accumulation and acid production of the dental caries pathogen . Prior research with the non-prenylated stilbenes, resveratrol and piceatannol, has shown that these molecules are active against . Here we sought to determine if the addition of a prenyl group to the stilbene backbone increased anti- activities. Two prenylated stilbenes, arachidin-1 and arachidin-3, were produced using a peanut hairy root production system. Compared to resveratrol and piceatannol, both arachidin-1 and arachidin-3 led to greater inhibition of planktonic growth. This effect also led to reduced biofilm formation, by inhibiting growth, instead of a specific action against biofilm cells. Lastly, sub-MIC concentrations of arachidin-3 reduced the acid production of above the 'critical pH' that leads to tooth enamel erosion. In summary, stilbenoids have anti- activity, and prenylation enhances this activity.
在本研究中，我们评估了异戊烯基化花生芪类化合物对龋齿病原体生长、生物膜积累和产酸的影响。此前对非异戊烯基化芪类化合物白藜芦醇和3,4',5-三羟基芪的研究表明，这些分子具有抗……活性。在此，我们试图确定在芪类骨架上添加异戊烯基是否会增强其抗……活性。使用花生毛状根生产系统制备了两种异戊烯基化芪类化合物花生四烯酸-1和花生四烯酸-3。与白藜芦醇和3,4',5-三羟基芪相比，花生四烯酸-1和花生四烯酸-3对浮游生长的抑制作用更强。这种作用还通过抑制生长而非对生物膜细胞的特异性作用，减少了生物膜的形成。最后，低于最低抑菌浓度的花生四烯酸-3降低了……在导致牙釉质侵蚀的“临界pH值”以上的产酸量。总之，芪类化合物具有抗……活性，而异戊烯基化增强了这种活性。
