Zhu Chao, Liu Qimin, Wang Yang, Wang Xiaolin, Ma Yuxuan, Yang Fangxia, Dong Wuzi, Ji Hong
College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China.
Biology Research Centre of Qin Mountains Wildlife, Northwest A&F University, Yangling, Shaanxi 712100, China.
Food Chem X. 2023 Dec 21;21:101088. doi: 10.1016/j.fochx.2023.101088. eCollection 2024 Mar 30.
The production of selenium-enriched fish contributes to alleviating selenium deficiency for humans. In this study, selenium nanoparticles (SeNPs) comparable in bioavailability to selenomethionine (SeMet), increased SeMet content in () muscle. Additionally, dietary SeNPs significantly enhanced selenocysteine (SeCys) and methylselenocysteine (MeSeCys) levels in muscle. The effect of SeNPs on selenium speciation in grass carp muscle was consistent with results. SeCys and MeSeCys showed antioxidant capacity in HEK293T cells, indicating enhanced health benefits of Se-enriched fish produced using SeNPs. Furthermore, the addition of 0.3 mg/kg SeNPs significantly improved the flesh quality of by reducing the content of crude fat and heavy metals, as well as increasing the levels of crude protein, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and the ratio of n-3/n-6 polyunsaturated fatty acids (PUFAs). Therefore, selenium-enriched fish produced from SeNPs is a good source for improving human dietary selenium intake.
富硒鱼的生产有助于缓解人类的硒缺乏状况。在本研究中，生物利用度与硒代蛋氨酸（SeMet）相当的硒纳米颗粒（SeNPs）增加了（）肌肉中的SeMet含量。此外，日粮中的SeNPs显著提高了（）肌肉中硒代半胱氨酸（SeCys）和甲基硒代半胱氨酸（MeSeCys）的水平。SeNPs对草鱼肌肉中硒形态的影响与（）结果一致。SeCys和MeSeCys在HEK293T细胞中表现出抗氧化能力，表明使用SeNPs生产的富硒鱼对健康的益处增强。此外，添加0.3 mg/kg的SeNPs通过降低粗脂肪和重金属含量，以及提高粗蛋白、二十碳五烯酸（EPA）、二十二碳六烯酸（DHA）水平和n-3/n-6多不饱和脂肪酸（PUFA）比例，显著改善了（）的鱼肉品质。因此，由SeNPs生产的富硒鱼是改善人类膳食硒摄入量的良好来源。
