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Epigenetic silencing promotes pancreatic cancer growth by activating Wnt signaling.

作者信息

Du Qian, Zhang Meiying, Gao Aiai, He Tao, Guo Mingzhou

机构信息

Department of Gastroenterology and Hepatology, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, People's Republic of China.

Department of Gastroenterology and Hepatology, the First Medical Center, Chinese PLA General Hospital, Beijing, People's Republic of China.

出版信息

Cancer Biol Ther. 2024 Dec 31;25(1):2302924. doi: 10.1080/15384047.2024.2302924. Epub 2024 Jan 16.

DOI:10.1080/15384047.2024.2302924
PMID:38226836
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10793710/
Abstract

Pancreatic ductal adenocarcinoma (PDAC) is the most malignant tumor. Zinc finger and SCAN domain-containing protein 23 () is a new member of the SCAN domain family. The expression regulation and biological function remain to be elucidated. In this study, we explored the epigenetic regulation and the function of in PDAC. was methylated in 60.21% (171/284) of PDAC and its expression was regulated by promoter region methylation. The expression of inhibited cell proliferation, colony formation, migration, invasion, and induced apoptosis and G1/S phase arrest. suppressed Panc10.05 cell xenograft growth in mice. Mechanistically, inhibited Wnt signaling by interacting with myosin heavy chain 9 (MYH9) in pancreatic cancer cells. is frequently methylated in PDAC and may serve as a detective marker. suppresses PDAC cell growth both and .

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9696/10793710/51f1dd5bc355/KCBT_A_2302924_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9696/10793710/207103168dff/KCBT_A_2302924_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9696/10793710/0229a5a77d38/KCBT_A_2302924_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9696/10793710/fa592f94f5cb/KCBT_A_2302924_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9696/10793710/51f1dd5bc355/KCBT_A_2302924_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9696/10793710/207103168dff/KCBT_A_2302924_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9696/10793710/0229a5a77d38/KCBT_A_2302924_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9696/10793710/fa592f94f5cb/KCBT_A_2302924_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9696/10793710/51f1dd5bc355/KCBT_A_2302924_F0004_OC.jpg

相似文献

[1]
Epigenetic silencing promotes pancreatic cancer growth by activating Wnt signaling.

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[2]
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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
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Biomed Pharmacother. 2017-9-7

[10]
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引用本文的文献

[1]
Research Progress on the Functional Regulation Mechanisms of ZKSCAN3.

Biomolecules. 2025-7-14

[2]
A novel lncRNA, Lnc21q22.11, suppresses gastric cancer growth by inhibiting MEK/ERK pathway.

Epigenetics. 2025-12

[3]
Allele-specific vitamin D receptor binding is associated with pediatric-onset multiple sclerosis.

Mult Scler J Exp Transl Clin. 2025-5-27

[4]
Placental malaria induces a unique methylation profile associated with fetal growth restriction.

Epigenetics. 2025-12

[5]
Rare genetic associations with human lifespan in UK Biobank are enriched for oncogenic genes.

Nat Commun. 2025-2-28

[6]
Role of miRNA‑145‑5p in cancer (Review).

Oncol Rep. 2025-3

[7]
Genetic associations with human longevity are enriched for oncogenic genes.

medRxiv. 2024-8-1

[8]
Epigenetic silencing of promotes hepatocellular carcinoma growth by activating PI3K/AKT signaling.

Epigenomics. 2024

本文引用的文献

[1]
RASSF1A promotes ATM signaling and methylation is a synthetic lethal marker for ATR inhibitors.

Epigenomics. 2023-11

[2]
Zinc finger and SCAN domain-containing protein 18 is a potential DNA methylation-modified tumor suppressor and biomarker in breast cancer.

Front Endocrinol (Lausanne). 2023

[3]
TM4SF1 upregulates MYH9 to activate the NOTCH pathway to promote cancer stemness and lenvatinib resistance in HCC.

Biol Direct. 2023-4-17

[4]
Pancreatic cancer: Advances and challenges.

Cell. 2023-4-13

[5]
SAMD9 Promotes Postoperative Recurrence of Esophageal Squamous Cell Carcinoma by Stimulating MYH9-Mediated GSK3β/β-Catenin Signaling.

Adv Sci (Weinh). 2023-4

[6]
Cancer epigenetics in clinical practice.

CA Cancer J Clin. 2023

[7]
Epigenetic silencing of JAM3 promotes esophageal cancer development by activating Wnt signaling.

Clin Epigenetics. 2022-12-2

[8]
NAP1L5 targeting combined with MYH9 Inhibit HCC progression through PI3K/AKT/mTOR signaling pathway.

Aging (Albany NY). 2022-11-11

[9]
MYH9 is a novel cancer stem cell marker and prognostic indicator in esophageal cancer that promotes oncogenesis through the PI3K/AKT/mTOR axis.

Cell Biol Int. 2022-12

[10]
Role of the WNT/β-catenin/ZKSCAN3 Pathway in Regulating Chromosomal Instability in Colon Cancer Cell lines and Tissues.

Int J Mol Sci. 2022-8-18

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