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表观遗传沉默通过激活Wnt信号通路促进胰腺癌生长。

Epigenetic silencing promotes pancreatic cancer growth by activating Wnt signaling.

作者信息

Du Qian, Zhang Meiying, Gao Aiai, He Tao, Guo Mingzhou

机构信息

Department of Gastroenterology and Hepatology, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, People's Republic of China.

Department of Gastroenterology and Hepatology, the First Medical Center, Chinese PLA General Hospital, Beijing, People's Republic of China.

出版信息

Cancer Biol Ther. 2024 Dec 31;25(1):2302924. doi: 10.1080/15384047.2024.2302924. Epub 2024 Jan 16.

DOI:10.1080/15384047.2024.2302924
PMID:38226836
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10793710/
Abstract

Pancreatic ductal adenocarcinoma (PDAC) is the most malignant tumor. Zinc finger and SCAN domain-containing protein 23 () is a new member of the SCAN domain family. The expression regulation and biological function remain to be elucidated. In this study, we explored the epigenetic regulation and the function of in PDAC. was methylated in 60.21% (171/284) of PDAC and its expression was regulated by promoter region methylation. The expression of inhibited cell proliferation, colony formation, migration, invasion, and induced apoptosis and G1/S phase arrest. suppressed Panc10.05 cell xenograft growth in mice. Mechanistically, inhibited Wnt signaling by interacting with myosin heavy chain 9 (MYH9) in pancreatic cancer cells. is frequently methylated in PDAC and may serve as a detective marker. suppresses PDAC cell growth both and .

摘要

胰腺导管腺癌（PDAC）是最具恶性的肿瘤。含锌指和SCAN结构域蛋白23（）是SCAN结构域家族的新成员。其表达调控和生物学功能仍有待阐明。在本研究中，我们探讨了其在PDAC中的表观遗传调控及功能。在60.21%（171/284）的PDAC中发生甲基化，其表达受启动子区域甲基化调控。的表达抑制细胞增殖、集落形成、迁移、侵袭，并诱导凋亡和G1/S期阻滞。抑制小鼠体内Panc10.05细胞异种移植瘤生长。机制上，通过与胰腺癌细胞中的肌球蛋白重链9（MYH9）相互作用抑制Wnt信号通路。在PDAC中经常发生甲基化，可能作为一种检测标志物。在体内和体外均抑制PDAC细胞生长。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9696/10793710/51f1dd5bc355/KCBT_A_2302924_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9696/10793710/207103168dff/KCBT_A_2302924_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9696/10793710/0229a5a77d38/KCBT_A_2302924_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9696/10793710/fa592f94f5cb/KCBT_A_2302924_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9696/10793710/51f1dd5bc355/KCBT_A_2302924_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9696/10793710/207103168dff/KCBT_A_2302924_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9696/10793710/0229a5a77d38/KCBT_A_2302924_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9696/10793710/fa592f94f5cb/KCBT_A_2302924_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9696/10793710/51f1dd5bc355/KCBT_A_2302924_F0004_OC.jpg

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