Chen Zeshan, Qin Yijue
Department of Traditional Chinese Medicine, Guangxi Zhuang Autonomous Region People's Hospital, Nanning, Guangxi 530016, P.R. China.
Oncol Rep. 2025 Mar;53(3). doi: 10.3892/or.2025.8872. Epub 2025 Jan 31.
MicroRNA‑145‑5p (miRNA‑145‑5p) is a short non‑coding RNA located at chromosome 5q33.1, which has gained significant attention in several aspects of cellular regulation and biological functions. In malignant tumours, miRNA‑145‑5p may function as either a tumour suppressor or an oncogene, affecting tumour progression by targeting downstream genes or modulating their expression through upstream regulators. However, the full extent of miRNA‑145‑5p's role in cancer has remained to be determined. This review provides an overview of the role of miRNA‑145‑5p in cancer, investigates its potential as a biomarker for diagnosis, prognosis and treatment response, and evaluates its influence on cancer chemotherapy and radiotherapy. Finally, current strategies for systemic delivery of miRNA‑145‑5p in cancer therapies are summarized.
微小RNA-145-5p（miRNA-145-5p）是一种位于5号染色体q33.1区域的短链非编码RNA，它在细胞调控和生物学功能的多个方面已受到广泛关注。在恶性肿瘤中，miRNA-145-5p既可以作为肿瘤抑制因子发挥作用，也可以作为癌基因，通过靶向作用于下游基因或通过上游调节因子调控其表达来影响肿瘤进展。然而，miRNA-145-5p在癌症中的全部作用仍有待确定。本综述概述了miRNA-145-5p在癌症中的作用，探讨了其作为诊断、预后和治疗反应生物标志物的潜力，并评估了其对癌症化疗和放疗的影响。最后，总结了目前在癌症治疗中系统性递送miRNA-145-5p的策略。
