Zhan Yuquan
Department of Endocrinology, Jinan Third People's Hospital, Jinan, China -
Minerva Endocrinol (Torino). 2025 Jun;50(2):201-208. doi: 10.23736/S2724-6507.23.04073-3. Epub 2024 Jan 16.
The association between betatrophin level and type 2 diabetes mellitus (T2DM) is a subject of controversy, and the reasons for conflicting results have been poorly explained. To address this gap, we conducted a meta-analysis of relevant studies to obtain a more comprehensive estimate and draw a more accurate conclusion.
This study included literature published up to June 2023. We searched for relevant studies in the Web of Science and PubMed databases. We utilized STATA 12.0 software to calculate the standard mean difference (SMD) and 95% confidence interval (CI) to compare circulating betatrophin levels between individuals with T2DM and healthy controls (HCs).
The meta-analysis revealed a significantly higher circulating betatrophin level in individuals with T2DM compared to HC, using a random effects model [mean value of betatrophin level (T2DM vs. HC): 388,685.23 vs. 304,857.04 pg/mL; SMD=1.37; 95%CI: 1.01, 1.73]. Subgroup analysis indicated a higher circulating betatrophin level in T2DM compared to HC among Asian individuals, while no significant difference in circulating betatrophin level was observed between T2DM and HC among Caucasian individuals (Asian: SMD=1.65; 95%CI: 1.23, 2.06; Caucasian: SMD=0.50; 95%CI: -0.21, 1.20). Additionally, subgroup analysis revealed increased plasma and serum betatrophin levels in T2DM compared to HC (plasma: SMD=1.30; 95%CI: 0.72, 1.88; serum: SMD=1.47; 95%CI: 0.98, 1.96).
This meta-analysis provides evidence of elevated levels of betatrophin in individuals with T2DM, suggesting that betatrophin may serve as a potential diagnostic biomarker for T2DM.
β-促胰岛素分泌素水平与2型糖尿病（T2DM）之间的关联存在争议，且对结果相互矛盾的原因解释不足。为填补这一空白，我们对相关研究进行了荟萃分析，以获得更全面的估计并得出更准确的结论。
本研究纳入截至2023年6月发表的文献。我们在科学网和PubMed数据库中检索相关研究。我们使用STATA 12.0软件计算标准化均数差（SMD）和95%置信区间（CI），以比较T2DM患者和健康对照（HC）的循环β-促胰岛素分泌素水平。
荟萃分析显示，使用随机效应模型，T2DM患者的循环β-促胰岛素分泌素水平显著高于HC [β-促胰岛素分泌素水平的均值（T2DM与HC）：388,685.23对304,857.04 pg/mL；SMD = 1.37；95%CI：1.01，1.73]。亚组分析表明，亚洲个体中T2DM患者的循环β-促胰岛素分泌素水平高于HC，而白种人个体中T2DM与HC的循环β-促胰岛素分泌素水平无显著差异（亚洲人：SMD = 1.65；95%CI：1.2, 2.06；白种人：SMD = 0.50；95%CI：-0.21，1.20）。此外，亚组分析显示，与HC相比，T2DM患者的血浆和血清β-促胰岛素分泌素水平升高（血浆：SMD = 1.30；95%CI：0.72，1.88；血清：SMD = 1.47；95%CI：0.98，1.96）。
这项荟萃分析提供了T2DM患者β-促胰岛素分泌素水平升高的证据，表明β-促胰岛素分泌素可能作为T2DM的潜在诊断生物标志物。
