Carrero Laura, Antequera Desireé, Municio Cristina, Carro Eva
Group of Neurodegenerative Diseases, Hospital Universitario 12 de Octubre Research Institute (imas12), Madrid, Spain; Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), ISCIII, Madrid, Spain.
PhD Program in Neuroscience, Autonoma de Madrid University, Madrid, Spain.
Neural Regen Res. 2024 Sep 1;19(9):1967-1972. doi: 10.4103/1673-5374.390962. Epub 2023 Dec 15.
Dysfunction in circadian rhythms is a common occurrence in patients with Alzheimer's disease. A predominant function of the retina is circadian synchronization, carrying information to the brain through the retinohypothalamic tract, which projects to the suprachiasmatic nucleus. Notably, Alzheimer's disease hallmarks, including amyloid-β, are present in the retinas of Alzheimer's disease patients, followed/associated by structural and functional disturbances. However, the mechanistic link between circadian dysfunction and the pathological changes affecting the retina in Alzheimer's disease is not fully understood, although some studies point to the possibility that retinal dysfunction could be considered an early pathological process that directly modulates the circadian rhythm.
昼夜节律功能障碍在阿尔茨海默病患者中很常见。视网膜的一个主要功能是昼夜同步，通过视网膜下丘脑束将信息传递到大脑，该束投射到视交叉上核。值得注意的是，阿尔茨海默病的特征，包括β淀粉样蛋白，存在于阿尔茨海默病患者的视网膜中，并伴有结构和功能紊乱。然而，尽管一些研究指出视网膜功能障碍可能被视为直接调节昼夜节律的早期病理过程，但昼夜节律功能障碍与阿尔茨海默病中影响视网膜的病理变化之间的机制联系尚未完全明确。
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