Pathology Department, Faculty of Medicine, Fayoum University, Faiyum, Egypt.
El-khaleya Labs for Histopathology, Giza, Egypt.
J Cutan Pathol. 2024 May;51(5):329-331. doi: 10.1111/cup.14587. Epub 2024 Jan 16.
A 52-year-old female presented with labial ulcer of 4-month duration. Examination showed 1 cm × 1 cm single superficial ulcer in the right labium majus. Excision was done, and histopathologic examination revealed surface ulceration and dermal invasion by epithelial neoplasm formed of biphasic proliferation of squamoid and gland-forming cells. Immunohistochemical staining with p63 showed nuclear staining of the squamoid nests and was negative in areas with glandular differentiation, while epithelial membrane antigen and carcinoembryonic antigen highlighted the glandular elements. The case was diagnosed as primary cutaneous adenosquamous carcinoma (ASC). ASC is an uncommon malignant cutaneous neoplasm that is more aggressive than conventional squamous cell carcinoma. There are a few reports of ASC that presented as an erythematous papule or plaque with a preference for the head, neck, or upper extremities. We report a novel case of vulval ASC presented as a superficial ulcer, which is considered a unique site, and its clinical presentation.
一位 52 岁女性因外阴溃疡 4 个月就诊。检查发现右侧大阴唇有 1cm×1cm 的单发浅表溃疡。行切除术，组织病理学检查显示表面溃疡和真皮上皮性肿瘤侵犯，由鳞状和形成腺体的细胞双相增生形成。p63 的免疫组化染色显示鳞状巢的核染色，在具有腺体分化的区域为阴性，而上皮膜抗原和癌胚抗原则突出显示腺体成分。该病例诊断为原发性皮肤腺鳞癌（ASC）。ASC 是一种罕见的恶性皮肤肿瘤，比传统的鳞状细胞癌更具侵袭性。有几例 ASC 表现为红斑丘疹或斑块，多见于头颈部或上肢。我们报告了一例外阴 ASC 的新病例，表现为浅表溃疡，这被认为是一个独特的部位及其临床表现。
