Moragas A, Serrano A, Torán N
Pediatr Pathol. 1986;6(1):111-7. doi: 10.3109/15513818609025929.
The case of a 3-month-old infant who died with an acute form of visceral leishmaniasis is reported. The liver presented an unusual pattern with widespread patchy cellular necrosis besides marked reticulin proliferation and some fibrosis. The marked systemic histiocytic proliferation contrasted with the paucity of Leishman-Donovan bodies, responsible for the negativity of two bone marrow aspirates and a needle biopsy of the liver. Visceral leishmaniasis must be considered in the differential diagnosis of cholestatic syndromes in infancy.
报告了一例3个月大婴儿死于急性内脏利什曼病的病例。肝脏呈现出异常模式，除了明显的网状纤维增生和一些纤维化外，还存在广泛的斑片状细胞坏死。显著的全身组织细胞增生与利什曼-多诺万小体的稀少形成对比，这导致两次骨髓穿刺和一次肝脏针吸活检结果均为阴性。在婴儿胆汁淤积综合征的鉴别诊断中必须考虑内脏利什曼病。
