Wells T R, Landing B H, Galliani C A, Thomas R A
Pediatr Pathol. 1986;6(2-3):209-25. doi: 10.3109/15513818609037713.
Larynges from 17 patients with DiGeorge syndrome (DGS) and from 14 patients with tetralogy of Fallot (TOF) (11 non-DGS and 3 possible but unproven DGS) were dissected, measured, and compared to a control population of comparable body length. The patients with DGS and the 3 patients with TOF suspected of having DGS showed the following: small thyroid cartilages with increased anterior angle, abnormally short superior cornua, low ratio of mean superior cornual length to distance between superior cornual tips, and delayed time of maximal rate of increase in superior cornual length relative to increase in body length. The hypoplasia, delayed maximal growth rate and persistent fetal shape of the thyroid cartilage (predominantly a derivative of the fourth branchial arch) in DGS, indicates that the causative process in the syndrome affects not only the third and fourth branchial pouches, but also, by a contiguous field defect, other derivatives than great vessels of the fourth-sixth branchial arches.
对17例迪格奥尔格综合征（DGS）患者以及14例法洛四联症（TOF）患者（11例非DGS患者和3例可能但未经证实的DGS患者）的喉部进行了解剖、测量，并与身体长度相当的对照人群进行比较。DGS患者以及3例疑似患有DGS的TOF患者表现出以下特征：甲状软骨较小，前角增大，上角异常短，平均上角长度与上角尖端之间距离的比值较低，上角长度相对于身体长度的最大增长率增加时间延迟。DGS患者甲状软骨发育不全、最大生长速率延迟以及持续的胎儿形态（主要是第四鳃弓的衍生物）表明，该综合征的致病过程不仅影响第三和第四鳃囊，还通过相邻区域缺陷影响第四至第六鳃弓大血管以外的其他衍生物。
