Jyothi Lakavath, Datta Mousumi, Mitra Divyangana, Biswas Jhuma, Maitra Arghya, Kar Kaushik
Department of Obstetrics and Gynecology, Calcutta National Medical College and Hospital, Kolkata, West Bengal, India.
Department of Community Medicine, R. G. Kar Medical College and Hospital, Kolkata, West Bengal, India.
Int J Appl Basic Med Res. 2023 Oct-Dec;13(4):198-203. doi: 10.4103/ijabmr.ijabmr_179_23. Epub 2023 Dec 8.
Around 80% of preterm births (PTBs) occur spontaneously. Various biomarkers are being evaluated to assess the possible role of chorioamniotic inflammation in PTBs.
The aim of this study was to establish the accuracy of serum bio-markers( cut off values of ferritin and alpha-fetoprotein [AFP] at midtrimester) along with cervical length [CL] assessment to predict preterm delivery among low-risk women.
Three hundred low-risk pregnant women attending the antenatal clinic of a tertiary health care facility were included and underwent CL measurement during mid-trimester by transvaginal ultrasonography and their serum levels of ferritin and AFP were recorded. All were followed up till delivery.
Receptor-operated characteristic curves for ferritin, AFP, and CL were constructed. Area under curves and Youden Index calculated for each marker were very low (<0.5) which is statistically considered very poor for a screening test.
Serum ferritin and AFP together with CL measurement in the second trimester of pregnancy had poor discriminatory value in predicting preterm delivery among low-risk asymptomatic pregnant women.
约80%的早产为自然发生。目前正在评估各种生物标志物，以确定绒毛膜羊膜炎在早产中可能发挥的作用。
本研究旨在确定血清生物标志物（孕中期铁蛋白和甲胎蛋白[AFP]的临界值）联合宫颈长度[CL]评估在预测低风险女性早产方面的准确性。
纳入300名在三级医疗保健机构产前门诊就诊的低风险孕妇，在孕中期经阴道超声测量宫颈长度，并记录其血清铁蛋白和AFP水平。所有孕妇均随访至分娩。
构建了铁蛋白、AFP和CL的受试者操作特征曲线。计算得出的每个标志物的曲线下面积和尤登指数都非常低（<0.5），从统计学角度来看，这对于一项筛查试验来说是非常差的结果。
妊娠中期血清铁蛋白和AFP联合宫颈长度测量在预测低风险无症状孕妇早产方面的鉴别价值较差。
