Ankara Bilkent City Hospital, Pediatric Endocrinology Clinic, Ankara, Türkiye.
Ankara Bilkent City Hospital, Pediatric Radiology Clinic, Ankara, Türkiye.
Front Endocrinol (Lausanne). 2024 Jan 2;14:1316333. doi: 10.3389/fendo.2023.1316333. eCollection 2023.
The aim of this study was to investigate the frequency and distribution of intracranial pathologies in female patients between 8 and 9 years of age who were diagnosed with early puberty (rapidly progressive) through the evaluation of MRI images.
A total of 74 female patients diagnosed with central precocious puberty (CPP) (6-8 years) and rapidly progressive early puberty (RPEP) (8-9 years) were included in the study. The patients were categorized into two groups, normal and abnormal, based on the findings from their MRI scans. Recent literature has classified abnormal MRI findings into three groups: pathological findings, findings with a questionable relationship to CPP, and incidental findings. Furthermore, the patients were divided into four groups based on their MRI findings and whether they had CPP or RPEP : CPP +Normal MRI, RPEP + Normal MRI, CPP +Abnormal MRI, RPEP +Abnormal MRI.
Out of the 74 girls included in the study, 54% (n=40) showed normal MRI results, while abnormal MRI findings were detected in 46% (n = 34) of the cases. No malignant lesions were identified among cases with abnormal MRI findings. The occurrence of abnormal MRI findings was observed in 46% of the PP group and 45% of the RPEP group. Incidental findings were the most common MRI findings in both groups. The proportion of cases with pathological findings and findings with a questionable relationship to CPP was similar in both groups (p = 0.06). Basal luteinizing hormone (LH) concentration was found to be higher in the RPEP +Abnormal MRI group compared to the CPP ) +Normal MRI group (p = 0.01).
Our study is the first to investigate MRI findings in cases of rapidly progressive early puberty in the age range of 8-9 years. Our study demonstrates that there is no difference in terms of intracranial findings between cases of precocious puberty at the age of 6-8 years and cases of rapidly progressive early puberty aged 8-9.
本研究旨在通过 MRI 图像评估，调查 8-9 岁被诊断为早期（快速进展型）性早熟的女性患者颅内病变的频率和分布。
共纳入 74 例中枢性性早熟（CPP）（6-8 岁）和快速进展型早期性早熟（RPEP）（8-9 岁）患者。根据 MRI 扫描结果，将患者分为正常和异常两组。最近的文献将异常 MRI 结果分为三组：病理性发现、与 CPP 关系可疑的发现和偶发发现。此外，根据 MRI 结果和是否患有 CPP 或 RPEP，将患者分为四组：CPP+正常 MRI、RPEP+正常 MRI、CPP+异常 MRI、RPEP+异常 MRI。
在纳入研究的 74 名女孩中，54%（n=40）的 MRI 结果正常，46%（n=34）的病例发现异常 MRI 结果。异常 MRI 结果的病例中未发现恶性病变。PP 组和 RPEP 组的异常 MRI 结果发生率分别为 46%和 45%。两组最常见的 MRI 发现均为偶发发现。两组病理性发现和与 CPP 关系可疑的发现的比例相似（p=0.06）。RPEP+异常 MRI 组的基础黄体生成素（LH）浓度高于 CPP+正常 MRI 组（p=0.01）。
本研究首次调查了 8-9 岁快速进展型早期性早熟患者的 MRI 发现。本研究表明，6-8 岁性早熟和 8-9 岁快速进展型早期性早熟患者的颅内发现无差异。
