Wang Jinling, Zhan Shumin, Yuan Jinna, Ullah Rahim, Dong Guanping, Wu Wei, Huang Ke, Fu Junfen
Department of Endocrinology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Clin Endocrinol (Oxf). 2021 Aug;95(2):303-307. doi: 10.1111/cen.14462. Epub 2021 May 30.
Many studies show that brain lesions are the main cause of central precocious puberty (CPP) in males. However, the association rate has not been reported in China. This study aimed to assess the frequency of both abnormal and likely pathologic brain lesions by magnetic resonance imaging (MRI) in Chinese boys with CPP.
This is a retrospective cross-sectional single-centre study.
396 CPP boys were recruited from 2011 to 2019 in Children's Hospital, Zhejiang University School of Medicine, and 129 were eligible for our study.
Diagnosis age, bone age, weight (kg), height (cm), puberty stage, MRI results and levels of sexual hormone were analysed.
The number of CPP boys is increasing from 2011 to 2019 in China. Brain MRI findings were normal in 83.7% of CPP boys. Only 21 (16.3%) CPP boys were found with abnormal MRI findings including hamartoma, pineal cyst and other minor changes.
In China, there is an increasing trend of male CPP over the last decade and the main cause is idiopathic, rather than pathogenic brain lesions. Further investigations about the aetiology for CPP with pathological brain lesions are needed.
许多研究表明，脑部病变是男性中枢性性早熟（CPP）的主要原因。然而，中国尚未报道其关联率。本研究旨在评估中国CPP男孩通过磁共振成像（MRI）检测出的异常及可能的病理性脑部病变的发生率。
这是一项回顾性横断面单中心研究。
2011年至2019年期间，从浙江大学医学院附属儿童医院招募了396名CPP男孩，其中129名符合本研究条件。
分析诊断年龄、骨龄、体重（kg）、身高（cm）、青春期阶段、MRI结果和性激素水平。
2011年至2019年期间，中国CPP男孩的数量呈上升趋势。83.7%的CPP男孩脑部MRI检查结果正常。仅21名（16.3%）CPP男孩的MRI检查发现异常，包括错构瘤、松果体囊肿和其他轻微变化。
在过去十年中，中国男性CPP呈上升趋势，主要原因是特发性的，而非病理性脑部病变。需要进一步研究CPP合并病理性脑部病变的病因。
