用于治疗多种中枢神经系统疾病的α7烟碱型乙酰胆碱受体正向变构调节剂
Positive Allosteric Modulators of alpha7 Nicotinic Acetylcholine Receptor for the Treatment of Several Central Nervous System Diseases.
作者信息
Abdel-Magid Ahmed F
机构信息
Therachem Research Medilab, LLC, 100 Jade Park, Chelsea, Alabama 35043, United States.
出版信息
ACS Med Chem Lett. 2023 Dec 13;15(1):6-8. doi: 10.1021/acsmedchemlett.3c00520. eCollection 2024 Jan 11.
Abstract
The invention in this patent application relates to spirocyclopropane-2-carboxamide derivatives represented generally by formula 1. These compounds are positive allosteric modulators of α7 nAChR and may be useful in preventing, treating, or ameliorating central nervous system diseases and disorders such as cognitive impairments in Alzheimer's disease, Parkinson's disease, schizophrenia, and L-DOPA-induced dyskinesia as well as inflammation and cough.
摘要
本专利申请中的发明涉及一般由式1表示的螺环丙烷-2-甲酰胺衍生物。这些化合物是α7烟碱型乙酰胆碱受体的正变构调节剂，可用于预防、治疗或改善中枢神经系统疾病和病症，如阿尔茨海默病、帕金森病、精神分裂症和左旋多巴诱导的运动障碍中的认知障碍以及炎症和咳嗽。
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