Abdel-Magid Ahmed F
Therachem Research Medilab, LLC, 100 Jade Park, Chelsea, Alabama 35043, United States.
ACS Med Chem Lett. 2023 Dec 13;15(1):9-11. doi: 10.1021/acsmedchemlett.3c00521. eCollection 2024 Jan 11.
The invention in this patent application relates to 1-aminophthalazine derivatives represented generally by formula 1. These compounds are inhibitors of the interaction of the catalytic site of SOS1 with RAS-family proteins which are involved in controlling cell proliferation. They may potentially be used as a treatment for RAS mutant cancers such as pancreatic, lung, and colorectal cancers, cholangiocarcinoma, multiple myeloma, melanoma, and thyroid cancer.
本专利申请中的发明涉及一般由式1表示的1-氨基酞嗪衍生物。这些化合物是SOS1催化位点与参与控制细胞增殖的RAS家族蛋白相互作用的抑制剂。它们有可能用于治疗RAS突变型癌症，如胰腺癌、肺癌、结直肠癌、胆管癌、多发性骨髓瘤、黑色素瘤和甲状腺癌。
