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复发性微创肝切除术治疗CK7-CK20+非典型标志物表达的肝内胆管癌的长期肿瘤学控制：一例报告

Long-Term Oncological Control by Repeated Minimally Invasive Hepatectomy for Intrahepatic Cholangiocarcinoma Exhibiting Atypical Marker Expression of CK7-CK20+: A Case Report.

作者信息

Harada Kei, Fujikawa Takahisa, Uemoto Yusuke, Matsuoka Taisuke

机构信息

Surgery, Kokura Memorial Hospital, Kitakyushu, JPN.

出版信息

Cureus. 2023 Dec 16;15(12):e50639. doi: 10.7759/cureus.50639. eCollection 2023 Dec.

DOI:10.7759/cureus.50639
PMID:38229809
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10789588/
Abstract

There are few reports of repeated liver resections being performed multiple times for intrahepatic recurrence of intrahepatic cholangiocarcinoma (ICC). We performed five minimally invasive liver resections and two minimally invasive lung resections for ICC with metachronous intrahepatic recurrence and lung metastases. Pathological examination revealed that all resected tumors were moderately differentiated mass-forming ICC with immunohistochemical marker expression of CK7 negative and CK20 positive. We present this as a rare case of ICC with atypical marker expression in which long-term tumor control was achieved with multiple minimally invasive liver resections over 47 months from the initial diagnosis.

摘要

关于因肝内胆管癌（ICC）肝内复发而多次进行重复肝切除的报道很少。我们对伴有异时性肝内复发和肺转移的ICC进行了5次微创肝切除和2次微创肺切除。病理检查显示，所有切除的肿瘤均为中度分化的肿块型ICC，免疫组化标志物表达为CK7阴性、CK20阳性。我们将此作为一例罕见的具有非典型标志物表达的ICC病例进行报道，该病例自初次诊断起47个月内通过多次微创肝切除实现了长期肿瘤控制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2530/10789588/34d82165a6c7/cureus-0015-00000050639-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2530/10789588/4079bcf9f8d7/cureus-0015-00000050639-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2530/10789588/b3300dac8c46/cureus-0015-00000050639-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2530/10789588/c1eb6a23695c/cureus-0015-00000050639-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2530/10789588/34d82165a6c7/cureus-0015-00000050639-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2530/10789588/4079bcf9f8d7/cureus-0015-00000050639-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2530/10789588/b3300dac8c46/cureus-0015-00000050639-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2530/10789588/c1eb6a23695c/cureus-0015-00000050639-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2530/10789588/34d82165a6c7/cureus-0015-00000050639-i04.jpg

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本文引用的文献

1
Liver Cancer Study Group of Japan Clinical Practice Guidelines for Intrahepatic Cholangiocarcinoma.日本肝癌研究组肝内胆管癌临床实践指南
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The Prognostic Value of Cytokeratin and Sal-Like Protein 4 Expression in Hepatocellular Carcinoma and Intra-Hepatic Cholangiocarcinoma in Taiwan.
台湾肝细胞癌和肝内胆管细胞癌中细胞角蛋白和 Sal-Like 蛋白 4 表达的预后价值。
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CK7/CK19 index: A potential prognostic factor for postoperative intrahepatic cholangiocarcinoma patients.细胞角蛋白7/细胞角蛋白19指数：肝内胆管癌术后患者的一个潜在预后因素。
J Surg Oncol. 2018 Jun;117(7):1531-1539. doi: 10.1002/jso.25027. Epub 2018 Mar 7.
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The value of CDX2 and cytokeratins 7 and 20 expression in differentiating colorectal adenocarcinomas from extraintestinal gastrointestinal adenocarcinomas: cytokeratin 7-/20+ phenotype is more specific than CDX2 antibody.CDX2 和细胞角蛋白 7、20 表达在鉴别结直肠腺癌与肠外胃肠道腺癌中的价值：细胞角蛋白 7-/20+表型比 CDX2 抗体更具特异性。
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Proposal of progression model for intrahepatic cholangiocarcinoma: clinicopathologic differences between hilar type and peripheral type.肝内胆管癌进展模型的提议：肝门型与外周型的临床病理差异
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Clinicopathological prognostic factors and impact of surgical treatment of mass-forming intrahepatic cholangiocarcinoma.肿块型肝内胆管癌的临床病理预后因素及手术治疗的影响
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