Palm Marisha E, Thompson Dixie D, Edwards Terri, Swartz Kitt, Herzog Keith A, Bansal Shweta, Echalier Benjamin, DeHart Kristen Clasen, Denmark Signe, Wilson Jurran L, Nelson Sarah, Waddy Salina P, Dunsmore Sarah E, Atkinson Jane C, Wiley Ken, Hassani Sara, Dwyer Jamie P, Hanley Daniel F, Dean J Michael, Ford Daniel E
Tufts Medical Center, Boston, MA, USA.
Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, USA.
J Clin Transl Sci. 2023 Nov 6;7(1):e249. doi: 10.1017/cts.2023.675. eCollection 2023.
In 2016, the National Center for Advancing Translational Science launched the Trial Innovation Network (TIN) to address barriers to efficient and informative multicenter trials. The TIN provides a national platform, working in partnership with 60+ Clinical and Translational Science Award (CTSA) hubs across the country to support the design and conduct of successful multicenter trials. A dedicated Hub Liaison Team (HLT) was established within each CTSA to facilitate connection between the hubs and the newly launched Trial and Recruitment Innovation Centers. Each HLT serves as an expert intermediary, connecting CTSA Hub investigators with TIN support, and connecting TIN research teams with potential multicenter trial site investigators. The cross-consortium Liaison Team network was developed during the first TIN funding cycle, and it is now a mature national network at the cutting edge of team science in clinical and translational research. The CTSA-based HLT structures and the external network structure have been developed in collaborative and iterative ways, with methods for shared learning and continuous process improvement. In this paper, we review the structure, function, and development of the Liaison Team network, discuss lessons learned during the first TIN funding cycle, and outline a path toward further network maturity.
2016年，美国国立转化医学推进中心启动了试验创新网络（TIN），以解决高效且信息丰富的多中心试验所面临的障碍。TIN提供了一个全国性平台，与全国60多个临床与转化科学奖（CTSA）中心合作，支持成功开展多中心试验。每个CTSA中心都设立了一个专门的中心联络团队（HLT），以促进各中心与新成立的试验与招募创新中心之间的联系。每个HLT都作为专家中介，将CTSA中心的研究人员与TIN的支持联系起来，并将TIN研究团队与潜在的多中心试验点研究人员联系起来。跨联盟联络团队网络是在TIN的第一个资助周期内建立的，现在已成为临床和转化研究团队科学前沿的成熟全国性网络。基于CTSA的HLT结构和外部网络结构是以协作和迭代的方式发展起来的，采用了共享学习和持续流程改进的方法。在本文中，我们回顾了联络团队网络的结构、功能和发展情况，讨论了在TIN的第一个资助周期中吸取的经验教训，并概述了进一步实现网络成熟的途径。
