State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
Key Laboratory of Luminescence Analysis and Molecular Sensing, Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.
Environ Sci Technol. 2024 Jan 30;58(4):1832-1841. doi: 10.1021/acs.est.3c07108. Epub 2024 Jan 17.
The massive production of plastics causes the ubiquitous existence of microplastics (MPs) in the biota, therefore, posing exposure risks and potential health concerns to human beings. However, the exact mechanisms of MPs-induced toxicities and abnormalities are largely unknown. In this study, we developed a mouse model of gavage polystyrene microplastics (PS MPs) for 30 days. We found that PS MPs can damage the intestinal barrier, accumulate in the liver tissue, and cause injury. The liver and intestine are both highly associated with bile acid (BA) metabolism. Indeed, we found that PS MPs dysregulate BA synthesis and efflux-related gene expression in the liver, causing cholestasis. Tandemly, PS MPs alter the ratio of primary to secondary BA in the feces by affecting the composition of the intestinal flora. At last, PS MPs alter mice's fecal BA profile, which affects normal BA metabolism. Taken together, the present study provides robust data on the mechanism of toxicity of MPs causing the disturbance of BA metabolism via a 4-step gut-liver loop.
大量塑料的生产导致微塑料（MPs）在生物群中无处不在，因此对人类造成暴露风险和潜在的健康问题。然而，MPs 诱导毒性和异常的确切机制在很大程度上尚不清楚。在本研究中，我们建立了灌胃聚苯乙烯微塑料（PS MPs）30 天的小鼠模型。我们发现 PS MPs 可破坏肠道屏障，在肝组织中积累，并造成损伤。肝脏和肠道都与胆汁酸（BA）代谢密切相关。事实上，我们发现 PS MPs 会扰乱肝脏中 BA 合成和外排相关基因的表达，导致胆汁淤积。同时，PS MPs 通过影响肠道菌群的组成来改变粪便中初级和次级 BA 的比例。最后，PS MPs 改变了小鼠粪便中 BA 的特征，从而影响了正常的 BA 代谢。综上所述，本研究通过 4 步肠-肝循环提供了关于 MPs 毒性机制的有力数据，即 MPs 导致 BA 代谢紊乱。
Antioxidants (Basel). 2025-6-27
Zotero 插件