Laudien H, Freyer J, Erb R, Denzer D
Physiol Behav. 1986;38(5):621-8. doi: 10.1016/0031-9384(86)90255-6.
Goldfish, Carassius auratus auratus L. (Pisces, Cyprinidae), were trained by different kinds of training procedures under the influence of cycloheximide or puromycin, two inhibitors of the protein biosynthesis. After active avoidance training in a shuttle box an apparent amnesia was found only when the fish were exposed to a one day lasting isolation stress prior to training. If the animals were accustomed to isolation over a period of 20 days the inhibitors did not affect memory formation. After learning by positive reinforcement (food rewarded color discrimination) in groups under stress-free conditions, neither learning nor memory formation were impaired in spite of the presence of cycloheximide. It is suggested that the amnestic effect of the inhibitors is caused by isolation treatment. Lack of the additional stress, however, leads to memory formation.
金鱼，鲫属鲫种（鲤形目，鲤科），在蛋白质生物合成的两种抑制剂环己酰亚胺或嘌呤霉素的影响下，通过不同的训练程序进行训练。在穿梭箱中进行主动回避训练后，仅当鱼在训练前经历持续一天的隔离应激时，才会出现明显的失忆现象。如果动物在20天的时间里适应了隔离环境，抑制剂则不会影响记忆形成。在无应激条件下通过正强化（食物奖励颜色辨别）进行群体学习后，尽管存在环己酰亚胺，但学习和记忆形成均未受损。提示抑制剂的失忆作用是由隔离处理引起的。然而，缺乏额外的应激会导致记忆形成。
