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产后获得性 A 型血友病:病例报告。

Postpartum-acquired hemophilia A: case report.

机构信息

Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Perú.

Hospital Nacional Edgardo Rebagliati Martins, EsSalud, Lima, Perú.

出版信息

Rev Peru Med Exp Salud Publica. 2023 Apr-Jun;40(2):242-246. doi: 10.17843/rpmesp.2023.402.12593.

Abstract

Acquired hemophilia A is a rare bleeding disorder worldwide, characterized by the presence of inhibitory autoantibodies directed against a coagulation factor, most often factor VIII. There are several possible causes, and it can occur during the postpartum period. We present the case of a 34-year-old female patient with back pain, hematuria and a right gluteal hematoma, with no previous history of bleeding. She was transferred to the emergency department due to the extension of the hemorrhagic manifestations. Diagnosis was confirmed with the coagulation profile, mixing test and the assessment of factor VIII inhibitor tier. The case highlights the importance of considering this condition in a postpartum patient with persistent postoperative bleeding, extensive hematoma and no history of previous bleeding.

摘要

获得性血友病 A 是一种罕见的全球范围内的出血性疾病,其特征是存在针对凝血因子的抑制性自身抗体,最常见的是因子 VIII。有几种可能的原因,它可能发生在产后期间。我们介绍了一位 34 岁女性患者的病例,该患者有背痛、血尿和右臀部血肿,无既往出血史。由于出血表现的扩展,她被转至急诊部。通过凝血谱、混合试验和因子 VIII 抑制剂级别的评估来确认诊断。该病例强调了在产后患者中出现持续的术后出血、广泛的血肿且无既往出血史时,考虑这种情况的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2309/10953653/15f8d8b1bfa3/rpmesp-40-02-12593-g001.jpg

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