King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK.
Parkinson's Foundation Centre of Excellence at King's College Hospital, London, UK.
BMC Complement Med Ther. 2024 Jan 17;24(1):41. doi: 10.1186/s12906-023-04296-y.
To date, beneficial effects of multimodal exercise programmes on Parkinson's disease (PD) have focused on motor symptoms and little attention has been paid to the potential effects of such programmes on the non-motor symptoms of PD, which are now universally known as one of the key drivers of quality of life and a key unmet need. We aim to explore clinical effectiveness of a ballet-based dance programme in addressing non-motor and motor symptoms of Parkinson's disease across all stages of progression.
A randomised, single-blind, controlled trial of 160 people with Parkinson's across all motor stages (Participants will be stratified into three groups of motor advancement: Hoehn and Yahr (HY) stages I and II being Mild Group, HY Stage III being Moderate Group and HY Stages IV and V being Severe Group) will be randomly allocated to either an intervention or a control group using an independent randomisation body. The primary outcome is an improvement in non-motor symptoms as measured by the Movement Disorders Society Non-Motor Scale (MDS-NMS). The intervention protocol consists of 12 one-weekly dance sessions led by English National Ballet. Each session is followed by a 'tea and biscuit' social time. Control group follows standard clinical pathway and joins the 'tea and biscuit' to control for any positive effects of social interactions. All participants are assessed at baseline, immediately after completion of the intervention and 3-6 months later to explore any potential longitudinal effects.
To our knowledge, no adequately powered study has explored the effects of a dance-based intervention on non-motor symptoms of Parkinson's disease, assessing these on both holistic and granular levels. We also aim to stratify participants in accordance with their motor state as assessed by. HY staging to explore specific effects on the symptoms at the initial, moderate and complex stages of the disease. If successful, this trial provides first evidence on clinical effectiveness of a ballet-based dance intervention for symptoms of Parkinson's disease, assessed in a robust, rigorous manner.
NCT04719468.
迄今为止，多模式运动方案对帕金森病（PD）的有益影响主要集中在运动症状上，而对这类方案对 PD 的非运动症状的潜在影响关注甚少，现在普遍认为这些非运动症状是生活质量的关键驱动因素之一，也是未满足的关键需求之一。我们旨在探索基于芭蕾的舞蹈方案在解决帕金森病所有阶段的非运动和运动症状方面的临床效果。
这是一项针对所有运动阶段帕金森病患者的随机、单盲、对照试验（参与者将分为三组：Hoehn 和 Yahr（HY）分期 I 和 II 为轻度组，HY 分期 III 为中度组，HY 分期 IV 和 V 为重度组），使用独立的随机分组机构将其随机分配到干预组或对照组。主要结局是通过运动障碍协会非运动量表（MDS-NMS）测量的非运动症状的改善。干预方案包括由英国国家芭蕾舞团指导的 12 周每周一次的舞蹈课程。每次课程结束后，都会有一个“茶点”社交时间。对照组遵循标准临床路径，并参加“茶点”，以控制任何社交互动的积极影响。所有参与者在基线、干预完成后立即以及 3-6 个月后进行评估，以探索任何潜在的纵向影响。
据我们所知，没有足够有力的研究探讨过基于舞蹈的干预对帕金森病非运动症状的影响，评估这些症状的整体和细化水平。我们还旨在根据参与者的运动状态（由 HY 分期评估）进行分层，以探索该方案对疾病初始、中度和复杂阶段症状的具体影响。如果成功，这项试验将首次提供基于芭蕾的舞蹈干预对帕金森病症状的临床效果的证据，采用了严格而严谨的方法进行评估。
NCT04719468。
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