一种强效、长效多巴胺受体激动剂在人体中的药理作用。
Pharmacologic effects in man of a potent, long-acting dopamine receptor agonist.
作者信息
Lemberger L, Crabtree R E
出版信息
Science. 1979 Sep 14;205(4411):1151-3. doi: 10.1126/science.382359.
PMID:382359
Abstract
Single-dose administration of pergolide mesylate (100 to 400 micrograms) results in a dose-related inhibition of prolactin secretion which persists for more than 24 hours. During multiple-dose administration of pergolide, plasma prolactin concentrations remain markedly reduced (greater than 80 percnet) and gradually return to control levels several days after drug administration is discontinued.
摘要
单剂量给予甲磺酸培高利特（100至400微克）会导致与剂量相关的催乳素分泌抑制，这种抑制持续超过24小时。在甲磺酸培高利特多剂量给药期间，血浆催乳素浓度持续显著降低（大于80%），且在停药几天后逐渐恢复至对照水平。
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