Department of Gastrointestinal Colorectal Surgery, China-Japan Union Hospital of Jilin University, Changchun, 130033, China.
Inflammation. 2024 Aug;47(4):1127-1141. doi: 10.1007/s10753-023-01965-5. Epub 2024 Jan 18.
Auraptene (AUT) is widely known to possess both antioxidant and anti-inflammatory properties. This study attempted to evaluate the protective effects of AUT in dextran sodium sulfate (DSS)-induced colitis in mice and to determine the underlying molecular mechanisms. Our results suggest that AUT substantially minimizes the severity and worsening of DSS-induced colitis in mice, indicated by the lengthening of the colon, lower disease activity index, reduced oxidation levels, and attenuated inflammatory factors. Molecular studies revealed that AUT reduces the nuclear translocation of nuclear factor-κB (NF-κB), thereby inhibiting the expression of inflammatory factors. Additionally, AUT promotes the diversity of the intestinal flora in mice with colitis by increasing the number of beneficial bacteria such as Lactobacillaceae and lowering the number of harmful bacteria. In conclusion, AUT mitigates DSS-induced colitis by maintaining the integrity of the intestinal barrier and modulating the levels of the intestinal microbial species.
白皮杉醇（AUT）具有抗氧化和抗炎特性，这是众所周知的。本研究试图评估 AUT 在葡聚糖硫酸钠（DSS）诱导的结肠炎小鼠模型中的保护作用，并确定其潜在的分子机制。我们的结果表明，AUT 可显著减轻 DSS 诱导的结肠炎小鼠的严重程度和恶化，表现为结肠延长、疾病活动指数降低、氧化水平降低以及炎症因子减少。分子研究表明，AUT 可减少核因子-κB（NF-κB）的核转位，从而抑制炎症因子的表达。此外，AUT 通过增加有益菌（如乳杆菌科）的数量和降低有害菌的数量，促进结肠炎小鼠肠道菌群的多样性。总之，AUT 通过维持肠道屏障的完整性和调节肠道微生物种类的水平来减轻 DSS 诱导的结肠炎。
