硫酸伊沙康唑在儿科肿瘤和干细胞移植人群中的使用和疗效特征：单机构回顾性研究。
Characterization of the Use and Efficacy of Isavuconazonium Sulfate in a Pediatric Oncology and Stem Cell Transplant Population: A Single Institution Retrospective Review.
机构信息
Department of Pharmacy.
Department of Medicine, Infectious Diseases Service.
出版信息
J Pediatr Hematol Oncol. 2024 Mar 1;46(2):e143-e146. doi: 10.1097/MPH.0000000000002812. Epub 2024 Jan 17.
Abstract
Isavuconazonium sulfate (ISA) is a triazole antifungal approved for the treatment of invasive aspergillosis and mucormycosis in adults. This single-center, retrospective review of pediatric oncology and stem cell transplant patients receiving ISA for prophylaxis (n=20) or treatment (n=6) of invasive fungal disease (IFD) aims to characterize real-world clinical efficacy and toxicity of ISA in patients <18 years of age. Of 20 patients receiving ISA for prophylaxis, three patients had presumed breakthrough IFD (1 proven, 2 probable/possible). No adverse effects were attributed to ISA use or led to the discontinuation of therapy.
摘要
硫酸伊沙康唑（ISA）是一种三唑类抗真菌药物，批准用于治疗成人侵袭性曲霉病和毛霉病。本单中心回顾性研究纳入了接受 ISA 预防（n=20）或治疗（n=6）侵袭性真菌病（IFD）的儿科肿瘤和干细胞移植患者，旨在评估 ISA 在<18 岁患者中的真实世界临床疗效和毒性。在接受 ISA 预防的 20 例患者中，3 例患者疑似发生了 IFD 突破（1 例确诊，2 例可能/很可能）。无不良事件归因于 ISA 使用或导致治疗中断。
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