Department of Neurology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Metab Syndr Relat Disord. 2024 Mar;22(2):141-150. doi: 10.1089/met.2023.0098. Epub 2024 Jan 19.
To explore the associations of the metabolic syndrome (MetS) and individual components with macular thickness and volume among rural-dwelling Chinese older adults. This population-based cross-sectional study included 705 participants (age ≥60 years) derived from the MIND-China study. In 2018-2019, we collected data through face-to-face interview, clinical examination, optical coherence tomography (OCT) examination, and blood test. We measured macular thickness and volume using spectral-domain OCT. MetS was defined following the International Diabetes Federation (IDF) criteria, the IDF/American Heart Association (AHA) criteria, the National Cholesterol Education Program-Adult Treatment Panel III criteria, and the Chinese Diabetes Society (CDS) criteria. Data were analyzed with multivariable general linear models. MetS was significantly associated with thinner macula in central (multivariable-adjusted β = -5.29; 95% confidence interval: -9.31 to -1.26), parafoveal (-2.85; -5.73 to 0.04) and perifoveal regions (-4.37; -6.79 to -1.95) when using the IDF criteria, in the perifoveal regions (-3.82; -6.18 to -1.47) when using the IDF/AHA criteria, and in the central region (-5.63; -10.25 to -1.02) when using the CDS criteria, and with reduced macular volume when using the IDF (-0.16; -0.26 to -0.07) and IDF/AHA (-0.13; -0.22 to -0.04) criteria. In the parafoveal region, the IDF-defined MetS was significantly associated with thinner retina in men (β = -6.25; -10.94 to -1.56) but not in women. Abdominal obesity (-2.83; -5.41 to -0.25) and elevated fasting blood glucose (-2.65; -5.08 to -0.21) were associated with thinner macular thickness in the perifoveal region. MetS is associated with macular thinning and reduced macular volume among rural-dwelling older adults, and the associations vary by the defining criteria of MetS.
探讨代谢综合征（MetS）及其各组分与中国农村老年人群黄斑厚度和体积的关系。本研究为基于人群的横断面研究，共纳入了 705 名（年龄≥60 岁）参与者，数据来自中国认知与老龄化研究（MIND-China 研究）。于 2018-2019 年通过面对面访谈、临床检查、光学相干断层扫描（OCT）检查和血液检测收集数据。采用频域 OCT 测量黄斑厚度和体积。MetS 按照国际糖尿病联合会（IDF）、IDF/美国心脏协会（AHA）、美国国家胆固醇教育计划成人治疗专家组第三版（NCEP-ATP III）和中国糖尿病学会（CDS）标准进行定义。采用多变量一般线性模型分析数据。结果显示，按照 IDF 标准，MetS 与中央（多变量校正后β=-5.29；95%置信区间：-9.31 至-1.26）、旁中心（-2.85；-5.73 至 0.04）和中心旁（-4.37；-6.79 至-1.95）部位的黄斑变薄显著相关；按照 IDF/AHA 标准，MetS 与中心旁部位的黄斑变薄（-3.82；-6.18 至-1.47）相关；按照 CDS 标准，MetS 与中央部位的黄斑变薄（-5.63；-10.25 至-1.02）相关。按照 IDF 标准，MetS 与黄斑体积减少相关（-0.16；-0.26 至-0.07）；按照 IDF/AHA 标准，MetS 与黄斑体积减少相关（-0.13；-0.22 至-0.04）。在旁中心区域，IDF 定义的 MetS 与男性（β=-6.25；-10.94 至-1.56）但不是女性的视网膜变薄显著相关。腹型肥胖（-2.83；-5.41 至-0.25）和空腹血糖升高（-2.65；-5.08 至-0.21）与中心旁区域的黄斑变薄相关。结论：在农村老年人群中，MetS 与黄斑变薄和黄斑体积减少有关，其相关性因 MetS 的定义标准而异。
