Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine.
Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine.
Eur J Med Chem. 2024 Feb 15;266:116151. doi: 10.1016/j.ejmech.2024.116151. Epub 2024 Jan 14.
The neuropharmacological community has shown a strong interest in AMPA receptors as critical components of excitatory synaptic transmission during the last fifteen years. AMPA receptors, members of the ionotropic glutamate receptor family, allow rapid excitatory neurotransmission in the brain. AMPA receptors, which are permeable to sodium and potassium ions, manage the bulk of the brain's rapid synaptic communications. This study thoroughly examines the recent developments in AMPA receptor regulation, focusing on a shift from single chemical illustrations to a more extensive investigation of underlying processes. The complex interplay of these modulators in modifying the function and structure of AMPA receptors is the main focus, providing insight into their influence on the speed of excitatory neurotransmission. This research emphasizes the potential of AMPA receptor modulation as a therapy for various neurological disorders such as epilepsy and Alzheimer's disease. Analyzing these regulators' sophisticated molecular details enhances our comprehension of neuropharmacology, representing a significant advancement in using AMPA receptors for treating intricate neurological conditions.
在过去的十五年中，神经药理学领域对 AMPA 受体表现出了浓厚的兴趣，将其视为兴奋性突触传递的关键组成部分。AMPA 受体是离子型谷氨酸受体家族的成员，允许大脑中快速的兴奋性神经传递。AMPA 受体对钠离子和钾离子具有通透性，管理着大脑中大部分快速的突触通讯。本研究全面考察了 AMPA 受体调节的最新进展，重点关注从单一化学描述向更广泛的基础过程研究的转变。这些调节剂在调节 AMPA 受体功能和结构方面的复杂相互作用是主要关注点，深入了解它们对兴奋性神经传递速度的影响。这项研究强调了 AMPA 受体调节作为治疗各种神经障碍（如癫痫和阿尔茨海默病）的潜在疗法。分析这些调节剂的复杂分子细节，增强了我们对神经药理学的理解，代表着在使用 AMPA 受体治疗复杂神经疾病方面的重大进展。
