脉络丛体积作为复发缓解型多发性硬化症视网膜萎缩的标志物

Choroid plexus volume as a marker of retinal atrophy in relapsing remitting multiple sclerosis.

作者信息

Raghib Muhammad F, Bao Fen, Elkhooly Mahmoud, Bernitsas Evanthia

机构信息

Department of Neurology, Wayne State University School of Medicine, United States of America.

Department of Neurology, Wayne State University School of Medicine, United States of America; Department of Neurology, Southern Illinois University School of Medicine, Springfield, IL, United States of America; Department of Neurology and Psychiatry, Minia University, Minia, Egypt.

出版信息

J Neurol Sci. 2024 Feb 15;457:122884. doi: 10.1016/j.jns.2024.122884. Epub 2024 Jan 13.

DOI:10.1016/j.jns.2024.122884

PMID:38237367

Abstract

OBJECTIVE

To evaluate choroid plexus (CP) volume as a biomarker for predicting clinical disability and retinal layer atrophy in relapsing remitting multiple sclerosis (RRMS).

METHODS

Ninety-five RRMS patients and 26 healthy controls (HCs) underwent 3 T whole brain MRI, expanded disability status scale (EDSS) and optical coherence tomography (OCT). Fully automated intra-retinal segmentation was performed to obtain the volumes of the retinal nerve fiber layer (RNFL), combined ganglion cell layer -inner plexiform layer (GCIPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), retinal pigment epithelium (RPE), total macular volume (TMV) and papillomacular bundle (PMB). Automated segmentation of the CP within the lateral ventricles was performed and the choroid plexus volume (CPV) was normalized by total intracranial volume (TIV). Linear regression analysis and generalized estimating equation (GEE) models were applied to evaluate relationships between nCPV and EDSS, T2 lesion volume, disease duration, and retinal layer volumes, followed by Bonferroni correction analysis for multiple comparisons.

RESULTS

RRMS patients had larger tChPV compared to HCs (p < 0.001). After Bonferroni correction, there was a significant positive correlation between tChPV and EDSS (r = 0.25, p = 0.0002), disease duration (r = 0.30, p = 0.01), and T2 lesion volume (r = 0.39, p = 0.0000). A robust negative correlation was found between tChPV and RNFL (p < 0.001), GCIPL (p = 0.003), TMV (p = 0.0185), PMB (p < 0.0001), G (p = 0.04), T(p = 0.0001).

CONCLUSIONS

Our findings support the association of tChPV with disability and altered retinal integrity in RRMS.

摘要

目的

评估脉络丛（CP）体积作为预测复发缓解型多发性硬化症（RRMS）临床残疾和视网膜层萎缩的生物标志物。

方法

95例RRMS患者和26名健康对照者（HCs）接受了3T全脑MRI、扩展残疾状态量表（EDSS）和光学相干断层扫描（OCT）检查。进行全自动视网膜内分割以获取视网膜神经纤维层（RNFL）、联合神经节细胞层 - 内丛状层（GCIPL）、内核层（INL）、外丛状层（OPL）、外核层（ONL）、视网膜色素上皮（RPE）、黄斑总体积（TMV）和乳头黄斑束（PMB）的体积。对侧脑室内的CP进行自动分割，并将脉络丛体积（CPV）通过总颅内体积（TIV）进行标准化。应用线性回归分析和广义估计方程（GEE）模型评估标准化脉络丛体积（nCPV）与EDSS、T2病变体积、病程和视网膜层体积之间的关系，随后进行Bonferroni校正分析以进行多重比较。

结果

与HCs相比，RRMS患者的脉络丛总体积（tChPV）更大（p < 0.001）。经过Bonferroni校正后，tChPV与EDSS（r = 0.25，p = 0.0002）、病程（r = 0.30，p = 0.01）和T2病变体积（r = 0.39，p = 0.0000）之间存在显著正相关。在tChPV与RNFL（p < 0.001）、GCIPL（p = 0.003）、TMV（p = 0.0185）、PMB（p < 0.0001）、G（p = 0.04）、T（p = 0.0001）之间发现了强烈的负相关。