Department of Health Science, Medical School, University "Magna Graecia" of Catanzaro, Catanzaro, Italy.
Immuno-Genetics Lab, Department of Health Science, Medical School, University "Magna Graecia"of Catanzaro, Catanzaro, Italy.
APMIS. 2024 Dec;132(12):1026-1045. doi: 10.1111/apm.13378. Epub 2024 Jan 18.
The CD4 T-cell population plays a vital role in the adaptive immune system by coordinating the immune response against different pathogens. A significant transformation occurs in CD4 cells during an immune response, as they shift from a dormant state to an active state. This transformation leads to extensive proliferation, differentiation, and cytokine production, which contribute to regulating and coordinating the immune response. Th17 and Treg cells are among the most intriguing CD4 T-cell subpopulations in terms of genetics and metabolism. Gene expression modulation processes rely on and are linked to metabolic changes in cells. Lactylation is a new model that combines metabolism and gene modulation to drive Th17/Treg differentiation and functional processes. The focus of this review is on the metabolic pathways that impact lymphocyte gene modulation in a functionally relevant manner.
CD4 T 细胞群在适应性免疫系统中起着至关重要的作用，它协调着针对不同病原体的免疫反应。在免疫反应中，CD4 细胞发生显著转化，从休眠状态转变为活跃状态。这种转化导致广泛的增殖、分化和细胞因子产生，有助于调节和协调免疫反应。Th17 和 Treg 细胞是 CD4 T 细胞亚群中在遗传学和代谢方面最引人关注的细胞亚群之一。基因表达调控过程依赖于细胞代谢变化，并与之相关。乳酰化是一种新的模型，它将代谢和基因调节结合起来，驱动 Th17/Treg 分化和功能过程。本综述的重点是影响淋巴细胞基因调节的代谢途径，以一种功能相关的方式。
