Kerisnon Krishnan Thanamogan, Mohtarrudin Norhafizah, Wan Yaacob Wan Azura, Hussin Huzlinda
Department of Pathology, Hospital Raja Permaisuri Bainun, Perak, Malaysia.
Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia.
Malays J Med Sci. 2023 Dec;30(6):70-78. doi: 10.21315/mjms2023.30.6.8. Epub 2023 Dec 19.
Colorectal carcinoma (CRC) is the third most common cancer globally. In Malaysia, CRC is most prevalent among males and the second most common cancer among females. The CRC arises mainly from the adenocarcinoma sequence. Poorly differentiated clusters (PDCs) and tumour budding (TB) are believed to represent sequential steps in tumour growth. Therefore, this study analysed the association between PDC grades with clinicopathological and demographic characteristics of CRC.
A total of 47 CRC cases previously diagnosed by histopathological examination were reviewed for the presence of PDCs and graded accordingly. The association between PDC grades with clinicopathological and demographic characteristics was statistically analysed.
Out of the 47 cases with PDCs, most of them were of grade 3 (G3) ( = 27, 57.4%), followed by grade 2 (G2) ( = 13, 27.7%) and grade 1 (G1) ( = 7, 14.9%). Higher PDC grades (G2 and G3) were mainly observed in higher tumour stage (T); T3 ( = 26, 83.9%), T4 ( = 12, 92.3%), N1 ( = 20, 86.9%), N2 ( = 15, 100%). In addition, there was a significant association between PDC grades with the nodal stage (N) ( = 0.013) and the tumour, node and metastasis (TNM) stages ( = 0.012).
The PDC grades are useful for assessing the disease prognosis in CRC. A statistically significant association between PDC grades with N and TNM stages suggested that PDC grades are potential predictive parameters for invasive and metastatic risks in CRC.
结直肠癌（CRC）是全球第三大常见癌症。在马来西亚，CRC在男性中最为普遍，在女性中是第二大常见癌症。CRC主要起源于腺癌序列。低分化簇（PDCs）和肿瘤芽生（TB）被认为代表肿瘤生长的连续步骤。因此，本研究分析了PDC分级与CRC临床病理及人口统计学特征之间的关联。
回顾了47例先前经组织病理学检查确诊的CRC病例，检查是否存在PDCs并进行相应分级。对PDC分级与临床病理及人口统计学特征之间的关联进行统计学分析。
在47例有PDCs的病例中，大多数为3级（G3）（n = 27，57.4%），其次是2级（G2）（n = 13，27.7%）和1级（G1）（n = 7，14.9%）。较高的PDC分级（G2和G3）主要见于较高的肿瘤分期（T）；T3（n = 26，83.9%），T4（n = 12，92.3%），N1（n = 20，86.9%），N2（n = 15，100%）。此外，PDC分级与淋巴结分期（N）（P = 0.013）和肿瘤、淋巴结转移（TNM）分期（P = 0.012）之间存在显著关联。
PDC分级有助于评估CRC的疾病预后。PDC分级与N和TNM分期之间具有统计学意义的关联，表明PDC分级是CRC侵袭和转移风险的潜在预测参数。
