蜱传脑炎病毒（TBEV）疫苗接种的免疫原性以及年龄对类风湿关节炎患者体液和细胞TBEV特异性免疫反应的影响。

Immunogenicity of tick-borne-encephalitis-virus-(TBEV)-vaccination and impact of age on humoral and cellular TBEV-specific immune responses in patients with rheumatoid arthritis.

作者信息

Rack Christoph, Almanzar Giovanni, Schäfer Arne, Völkl Sebastian, Dobler Gerhard, Mutterer Angelika, Schmalzing Marc, Hick Sonja, Steimer Marie, Jahn Lydia, Fladerer Michael, Hartmann Gerhardt, Deininger Frank, Arbogast Martin, Sonnleitner Sissy, Walder Gernot, Feuchtenberger Martin, Prelog Martina

机构信息

Department of Pediatrics, Pediatric Rheumatology/Special Immunology, University Hospital Würzburg, 97080 Würzburg, Germany.

Department of Internal Medicine II, Department of Rheumatology/Clinical Immunology, University of Würzburg, 97080 Würzburg, Germany; Diabetes Zentrum Mergengtheim, Bad Mergentheim, Germany.

出版信息

Vaccine. 2024 Feb 6;42(4):745-752. doi: 10.1016/j.vaccine.2024.01.022. Epub 2024 Jan 18.

DOI:10.1016/j.vaccine.2024.01.022

PMID:38242736

Abstract

Inactivated vaccines, such as tick-borne-encephalitis-virus-(TBEV) vaccine, have been discussed as less immunogenic in elderly and in immunocompromised patients. In this controlled cross-sectional cohort study, the antibody and cellular responses after TBEV-vaccination were investigated in 36 rheumatoid arthritis (RA) patients and 112 healthy controls (HC) by evaluating IgG-anti-TBEV concentration, neutralization and relative avidity index (RAI). Cellular reactivity was assessed by IFNgamma-producing spot-forming-units (SFU) by ELISPOT assay and flow cytometry. RA patients showed lower IgG-anti-TBEV compared to HC, which were influenced by age at and time since last TBEV vaccination and disease duration. High-responders regarding cellular immunity and avidity were less frequent in RA compared to HC. RA patients who had received booster vaccinations were more likely to demonstrate higher IgG-anti-TBEV responses compared to those who had not. In conclusion, RA patients showed a negative effect of age on anti-TBEV-IgG and immunological benefits of timely booster vaccination are suggested.

摘要

灭活疫苗，如蜱传脑炎病毒（TBEV）疫苗，在老年人和免疫功能低下患者中的免疫原性较低，这一点已被讨论。在这项对照横断面队列研究中，通过评估IgG抗TBEV浓度、中和作用和相对亲和力指数（RAI），对36例类风湿性关节炎（RA）患者和112例健康对照（HC）接种TBEV疫苗后的抗体和细胞反应进行了研究。通过ELISPOT分析和流式细胞术，用产生IFNγ的斑点形成单位（SFU）评估细胞反应性。与HC相比，RA患者的IgG抗TBEV水平较低，这受到上次接种TBEV疫苗时的年龄、接种时间和病程的影响。与HC相比，RA患者中细胞免疫和亲和力高反应者较少。与未接受加强免疫的RA患者相比，接受过加强免疫的RA患者更有可能表现出更高的IgG抗TBEV反应。总之，RA患者年龄对抗TBEV-IgG有负面影响，提示及时进行加强免疫有免疫学益处。