Department of Geriatric Gastroenterology, the Second Medical Center and National Clinical Research Center of Geriatric Diseases, Chinese PLA General Hospital, Beijing, People's Republic of China.
Department of Geriatric Neurology, the Second Medical Center and National Clinical Research Center of Geriatric Diseases, Chinese PLA General Hospital, Beijing, People's Republic of China.
Tissue Eng Part B Rev. 2024 Oct;30(5):522-529. doi: 10.1089/ten.TEB.2023.0316. Epub 2024 Feb 14.
Endoscopic submucosal dissection (ESD) has been widely used in the early neoplasia of the esophagus. However, postoperative esophageal stenosis is a big problem, particularly when a large circumferential proportion of esophageal mucosa is resected. Currently, there are several methods available to prevent esophageal stenosis after ESD, including steroid administration, esophageal stent implantation, and endoscopic balloon dilation (EBD). However, the therapeutic effects of these are not yet satisfactory. Stem cell-based therapies has shown promising potential in reconstructing tissue structure and restoring tissue function. In this study, we discussed the current strategies for preventing esophageal stenosis after ESD and perspectives of stem cell-based therapies for the prevention of esophageal stenosis.
内镜黏膜下剥离术（ESD）已广泛应用于食管早期肿瘤。然而，术后食管狭窄是一个大问题，尤其是当大范围的食管黏膜被切除时。目前，有几种方法可用于预防 ESD 后食管狭窄，包括类固醇给药、食管支架植入和内镜球囊扩张（EBD）。然而，这些方法的治疗效果尚不理想。基于干细胞的治疗方法在重建组织结构和恢复组织功能方面显示出了很大的潜力。在本研究中，我们讨论了预防 ESD 后食管狭窄的当前策略和基于干细胞的治疗方法预防食管狭窄的前景。
