da Silva Santos Iara, Magalhaes Leticia Oliveira, Marra Roberta Katlen Fusco, da Silva Lima Camilo Henrique, Hamerski Lidilhone, Albuquerque Magaly Girao, da Silva Barbara Vasconcellos
Department of Organic Chemistry, Instituto de Pesquisas de Produtos Naturais Walter Mors, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Department of Organic Chemistry, Universidade Federal do Rio de Janeiro, Instituto de Química, Rio de Janeiro, Brazil.
Curr Med Chem. 2025;32(3):539-562. doi: 10.2174/0109298673285609231220111556.
COVID-19, an airborne disease caused by a betacoronavirus named SARS-- CoV-2, was officially declared a pandemic in early 2020, resulting in more than 770 million confirmed cases and over 6.9 million deaths by September 2023. Although the introduction of vaccines in late 2020 helped reduce the number of deaths, the global effort to fight COVID-19 is far from over. While significant progress has been made in a short period, the fight against SARS-CoV-2/COVID-19 and other potential pandemic threats continues. Like AIDS and hepatitis C epidemics, controlling the spread of COVID-19 will require the development of multiple drugs to weaken the virus's resistance to different drug treatments. Therefore, it is essential to continue developing new drug candidates derived from natural or synthetic small molecules. Coumarins are a promising drug design and development scaffold due to their synthetic versatility and unique physicochemical properties. Numerous examples reported in scientific literature, mainly by prospection, demonstrate their potential contribution to the rapid development of drugs against SARS-CoV-2/COVID-19 and other emergent and reemergent viruses.
2019冠状病毒病（COVID-19）是一种由名为严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的β冠状病毒引起的空气传播疾病，于2020年初被正式宣布为大流行病，截至2023年9月已导致超过7.7亿确诊病例和超过690万例死亡。尽管2020年末推出的疫苗有助于减少死亡人数，但全球抗击COVID-19的努力远未结束。虽然在短时间内取得了重大进展，但对抗SARS-CoV-2/COVID-19和其他潜在大流行威胁的斗争仍在继续。与艾滋病和丙型肝炎疫情一样，控制COVID-19的传播需要开发多种药物来削弱病毒对不同药物治疗的耐药性。因此，继续开发源自天然或合成小分子的新候选药物至关重要。香豆素因其合成的多功能性和独特的物理化学性质，是一种很有前景的药物设计和开发支架。科学文献中报道的大量实例，主要是通过勘探，证明了它们对快速开发抗SARS-CoV-2/COVID-19及其他新出现和再次出现病毒的药物的潜在贡献。
