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预测结节病患者死亡率的因素。

Predictors of Mortality in Sarcoidosis.

机构信息

Medicine Faculty, Department of Chest Disease, Firat University, Elazig 23200, Turkey.

出版信息

Clin Chest Med. 2024 Mar;45(1):175-183. doi: 10.1016/j.ccm.2023.06.006. Epub 2023 Jul 18.

Abstract

Sarcoidosis is a systemic granulomatous disorder that affects individuals of all racial/ethnic origins and occurs at any time of life. Spontaneous remission is frequent and may occur in 2 of 3 patients, while the remaining cases have chronic, progressive disease, with some patients presenting with organ- and life-threatening involvements. Many reports have investigated which features may be related to poor outcomes in patients with sarcoidosis. Pulmonary hypertension and respiratory failure from pulmonary fibrosis are the most common complications associated with the cause of death in sarcoidosis. Other major causes of death include cardiac, neurologic, hepatic involvement, and hemoptysis from aspergilloma.

摘要

结节病是一种系统性肉芽肿性疾病,可影响所有种族/民族的个体,发生于任何年龄段。自发性缓解很常见,可能发生于 2/3 的患者中,而其余病例则为慢性、进行性疾病,部分患者出现危及器官和生命的受累。许多研究报告调查了哪些特征可能与结节病患者的不良预后相关。肺动脉高压和肺纤维化导致的呼吸衰竭是结节病导致死亡的最常见并发症。其他主要死亡原因包括心脏、神经、肝脏受累以及曲霉菌引起的咯血。

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