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足部跖区罕见巨大滑膜肉瘤病例报告

A rare occurrence of a giant synovial sarcoma in the plantar region of the foot: A case report.

作者信息

Fadili Omar, Chrak Abdellah, Laffani Mohamed, El Adaoui Oussama, Messoudi Abdeljabbar, Fadili Mustapha

机构信息

Department of Trauma Surgery and Orthopaedics, Ibn Rochd University Hospital Center, Casablanca, Morocco; Faculty of Medicine and Pharmacy of Casablanca, Hassan II University, Morocco.

Department of Trauma Surgery and Orthopaedics, Ibn Rochd University Hospital Center, Casablanca, Morocco; Faculty of Medicine and Pharmacy of Casablanca, Hassan II University, Morocco.

出版信息

Int J Surg Case Rep. 2024 Feb;115:109268. doi: 10.1016/j.ijscr.2024.109268. Epub 2024 Jan 17.

Abstract

UNLABELLED

Introduction and Significance. Synovial sarcoma, accounting for 7-8 % of malignant sarcomas, typically manifests in adulthood, but it is noteworthy that adolescents and children make up 30 % of reported cases. Contrary to its name, this malignancy often originates from multipotent stem cells rather than the synovium. This report highlights a rare case involving a 23-year-old male with a localized synovial sarcoma in the plantar region, underscoring the importance of recognizing radiological signs for an accurate diagnosis.

CASE PRESENTATION

A 23-year-old male, a chronic smoker, presented with a 5-year history of a mass on the plantar region of the right foot. Following an excision biopsy, the tumor recurred after two years, significantly impacting mobility. Radiological imaging revealed a cloud-like soft tissue mass. Surgical biopsy confirmed biphasic synovial sarcoma. A multidisciplinary consultation guided the decision for transtibial amputation and adjuvant chemotherapy. Postoperatively, the patient experienced a superficial infection, effectively treated, with subsequent positive outcomes and successful prosthetic adaptation.

DISCUSSION

Synovial sarcoma, a rare and aggressive soft tissue malignancy, predominantly affects young individuals and often develops peri-articularly, presenting diagnostic challenges. Imaging modalities, particularly MRI, play a pivotal role in diagnosis, showcasing characteristic features. The primary treatment involves surgical intervention, with chemotherapy and radiotherapy contributing to local control. Despite advancements, recurrence rates remain significant, necessitating vigilant follow-up.

CONCLUSION

Synovial sarcoma of the extremities is characterized by insidious progression and a high metastatic risk. MRI, while nonspecific, is indispensable for diagnostic orientation, later confirmed through histological examination. Surgery remains the mainstay therapy, with radiotherapy and chemotherapy contributing to enhanced local control. The awareness of this rare malignancy and its diagnostic and therapeutic nuances is crucial for optimal patient management and outcomes.

摘要

未标注

引言与意义。滑膜肉瘤占恶性肉瘤的7 - 8%,通常在成年期发病,但值得注意的是,青少年和儿童占报告病例的30%。与其名称相反,这种恶性肿瘤通常起源于多能干细胞而非滑膜。本报告强调了一例罕见病例,一名23岁男性足底出现局限性滑膜肉瘤,强调了识别放射学征象以准确诊断的重要性。

病例介绍

一名23岁男性,长期吸烟,右足底肿物病史5年。切除活检后,肿瘤在两年后复发,严重影响活动能力。放射学影像显示为云雾状软组织肿块。手术活检证实为双相性滑膜肉瘤。多学科会诊指导了经胫骨截肢及辅助化疗的决策。术后,患者发生浅表感染,经有效治疗后取得了良好效果并成功适配假肢。

讨论

滑膜肉瘤是一种罕见且侵袭性强的软组织恶性肿瘤,主要影响年轻人,常发生于关节周围,带来诊断挑战。影像学检查,尤其是MRI,在诊断中起关键作用,显示出特征性表现。主要治疗方法为手术干预,化疗和放疗有助于局部控制。尽管取得了进展,但复发率仍然很高,需要密切随访。

结论

四肢滑膜肉瘤具有隐匿性进展和高转移风险的特点。MRI虽不具有特异性,但对诊断导向不可或缺,最终通过组织学检查得以证实。手术仍然是主要治疗方法,放疗和化疗有助于加强局部控制。认识这种罕见的恶性肿瘤及其诊断和治疗细微差别对于优化患者管理和治疗结果至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a937/10831870/a254b2d412bb/gr1.jpg

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