Department of Radiology, Faculty of Medicine, Kagawa University, Kagawa, Japan.
Department of Radiology, Faculty of Medicine, Kagawa University, Kagawa, Japan.
J Nucl Cardiol. 2024 Mar;33:101816. doi: 10.1016/j.nuclcard.2024.101816. Epub 2024 Jan 20.
We present a 77-year-old woman with wild-type ATTR cardiac amyloidosis (ATTR-CA) who presented with dyspnea, arrhythmia, and elevated NT-pro BNP. Initial imaging including cardiac MRI, PYP scintigraphy, PiB PET/CT and NaF PET/CT revealed cardiac abnormalities. Tafamidis treatment was initiated. After 14 months, symptomatic improvement and reduced NT-pro BNP were observed. Cardiac MRI and PYP scintigraphy showed no significant change and increased NaF accumulation, while PiB PET/CT showed decreased amyloid deposition, suggesting that it may be superior to NaF PET/CT in assessing the therapeutic effect of tafamidis in ATTR-CA.
我们报告一例 77 岁女性ATTR 型心肌淀粉样变（ATTR-CA）患者，以呼吸困难、心律失常和 NT-pro BNP 升高为表现。初始影像学检查包括心脏 MRI、PYP 闪烁显像、PiB PET/CT 和 NaF PET/CT，结果提示心脏异常。开始给予塔法米迪治疗。14 个月后，患者症状改善，NT-pro BNP 降低。心脏 MRI 和 PYP 闪烁显像未见明显变化，但 NaF 摄取增加，而 PiB PET/CT 显示淀粉样蛋白沉积减少，提示其在评估塔法米迪治疗 ATTR-CA 的疗效方面可能优于 NaF PET/CT。
