Department of Pathology, Hospital de Dénia, Alicante, Spain.
Department of Pathology, Charles University, Faculty of Medicine in Pilsen, Czech Republic.
Rev Esp Patol. 2024 Jan-Mar;57(1):67-70. doi: 10.1016/j.patol.2023.08.002. Epub 2023 Oct 28.
Sinonasal carcinomas represent a rare and diverse group of tumors, presenting diagnostic complexities due to their varied histological and molecular features. To ensure accurate differentiation among these malignancies, a systematic and stepwise approach is paramount. Even with the morphological similarities between poorly differentiated (non) keratinizing sinonasal squamous cell carcinoma (SNSCC) and DEK::AFF2 SNSCC, the two lesions are distinguishable using the surrogate immunohistochemical marker AFF2 or molecular testing for DEK::AFF2 mutation. We report a rare case of SMARCB1-retained DEK::AFF2 papillary non-keratinizing SNSCC in a 53-year-old female, who presented with a polypoid mass corresponding to the left middle turbinate. Following the surgical resection of the tumor and locoregional lymph nodes, adjuvant radiotherapy was administered to eradicate any residual cancer cells that may have remained after surgery.
鼻腔鼻窦癌是一组罕见且多样化的肿瘤，由于其组织学和分子特征的多样性，诊断较为复杂。为了确保准确地区分这些恶性肿瘤，系统的、逐步的方法至关重要。即使在低分化（非）角化型鼻腔鼻窦鳞状细胞癌（SNSCC）和 DEK::AFF2 SNSCC 之间存在形态学相似性，也可以使用替代免疫组织化学标志物 AFF2 或针对 DEK::AFF2 突变的分子检测来区分这两种病变。我们报告了一例罕见的 SMARCB1 保留的 DEK::AFF2 乳头状非角化型 SNSCC 病例，患者为 53 岁女性，表现为左中鼻甲对应部位的息肉样肿块。在肿瘤和局部淋巴结切除术后，给予辅助放疗以消灭手术切除后可能残留的任何癌细胞。
