The role of P2Y receptor in the pathogenesis of cardiovascular and inflammatory diseases.

The purinergic receptor P2Y receptor (P2YR) is a member of the G protein-coupled receptors (GPCR) family. P2YR is widely expressed in various cell types and plays a critical role in physiological processes, where it is activated by extracellular uridine diphosphate (UDP) and mobilizes Ca via the G protein pathway. We have recently discovered the pathophysiological role of P2YR in cardiovascular and inflammatory diseases, including inflammatory bowel disease and non-alcoholic fatty liver disease. Furthermore, we uncovered the redox-dependent internalization of P2YR. In this review, we provide a comprehensive overview of the pathophysiological activity of P2YR in cardiovascular and inflammatory diseases. Additionally, we discuss the concept of atypical internalization control of GPCRs, which may be applied in the prevention and treatment of intestinal inflammation and cardiovascular remodeling.