Laboratory of Prophylactic Pharmacology, Osaka Metropolitan University Graduate School of Veterinary Science, 1-58 Rinku-ohraikita, Izumisano, Osaka, 598-8531, Japan.
J Pharmacol Sci. 2024 Feb;154(2):108-112. doi: 10.1016/j.jphs.2024.01.003. Epub 2024 Jan 5.
The purinergic receptor P2Y receptor (P2YR) is a member of the G protein-coupled receptors (GPCR) family. P2YR is widely expressed in various cell types and plays a critical role in physiological processes, where it is activated by extracellular uridine diphosphate (UDP) and mobilizes Ca via the G protein pathway. We have recently discovered the pathophysiological role of P2YR in cardiovascular and inflammatory diseases, including inflammatory bowel disease and non-alcoholic fatty liver disease. Furthermore, we uncovered the redox-dependent internalization of P2YR. In this review, we provide a comprehensive overview of the pathophysiological activity of P2YR in cardiovascular and inflammatory diseases. Additionally, we discuss the concept of atypical internalization control of GPCRs, which may be applied in the prevention and treatment of intestinal inflammation and cardiovascular remodeling.
嘌呤能受体 P2Y 受体 (P2YR) 是 G 蛋白偶联受体 (GPCR) 家族的成员。P2YR 广泛表达于各种细胞类型中，在生理过程中发挥着关键作用，其通过 G 蛋白途径被细胞外二磷酸尿苷 (UDP) 激活并动员 Ca。我们最近发现 P2YR 在心血管和炎症性疾病中的病理生理作用，包括炎症性肠病和非酒精性脂肪肝疾病。此外，我们还揭示了 P2YR 的氧化还原依赖性内化。在这篇综述中，我们全面概述了 P2YR 在心血管和炎症性疾病中的病理生理活性。此外，我们还讨论了 GPCR 非典型内化控制的概念，这可能应用于预防和治疗肠道炎症和心血管重塑。
