DAMP Laboratory, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Department of Surgery, UT Southwestern Medical Center, Dallas, TX, USA.
Trends Cancer. 2024 May;10(5):417-429. doi: 10.1016/j.trecan.2024.01.002. Epub 2024 Jan 20.
Ferroptosis, a nonapoptotic form of cell death characterized by iron accumulation and uncontrolled lipid peroxidation, holds promise as a therapeutic approach in cancer treatment, alongside established modalities, such as chemotherapy, immunotherapy, and radiotherapy. However, recent research has raised concerns about its side effects, including damage to immune cells, hematopoietic stem cells, liver, and kidneys, the development of cachexia, and the risk of secondary tumor formation. In this review, we provide an overview of these emerging findings, with a specific emphasis on elucidating the underlying mechanisms, and underscore the critical significance of effectively managing side effects associated with targeted ferroptosis-based therapy.
铁死亡是一种非细胞凋亡形式的细胞死亡，其特征是铁积累和不受控制的脂质过氧化，除了化疗、免疫疗法和放疗等已确立的方法外，它在癌症治疗中具有很大的应用前景。然而，最近的研究引起了人们对其副作用的关注，包括对免疫细胞、造血干细胞、肝脏和肾脏的损伤、恶病质的发展以及继发性肿瘤形成的风险。在这篇综述中，我们提供了对这些新出现的发现的概述，特别强调阐明潜在的机制，并强调有效管理基于靶向铁死亡的治疗相关副作用的关键意义。
