Rynhoud Leigh, Kagee Ashraf
Stellenbosch University, South Africa.
J Health Psychol. 2024 Jun;29(7):674-679. doi: 10.1177/13591053231224124. Epub 2024 Jan 21.
This cross-sectional study aimed to explore the use of alcohol and drugs and the potential impact on adherence to medication for tuberculosis. Adult patients admitted to specialised tuberculosis hospitals in South Africa were assessed for drug use, alcohol use and adherence to tuberculosis medication. A total of 175 patients participated in the study; 32% reported harmful alcohol use, and 44% reported problematic use of drugs. Participants who used drugs were four times as likely (OR = 4.11, 95% CI (1.89, 8.91)) and those using alcohol were twice as likely (OR = 2.06, 95% CI (1.02, 5.08)) to be nonadherent to medication for tuberculosis. Prevalence of harmful/hazardous use of alcohol and other drugs was high and significantly correlated with poorer medication adherence. Routine screening for and treatment of substance use in patients on treatment for tuberculosis and ongoing monitoring of adherence to medication is recommended.
这项横断面研究旨在探讨酒精和药物的使用情况以及对结核病药物治疗依从性的潜在影响。对南非专科医院收治的成年结核病患者进行了药物使用、酒精使用及结核病药物治疗依从性评估。共有175名患者参与了该研究；32%的患者报告有有害饮酒行为，44%的患者报告有药物使用问题。使用药物的参与者不依从结核病药物治疗的可能性是未使用药物者的4倍（比值比=4.11，95%置信区间（1.89，8.91）），而饮酒者不依从的可能性是未饮酒者的2倍（比值比=2.06，95%置信区间（1.02，5.08））。酒精和其他药物的有害/危险使用患病率较高，且与较差的药物治疗依从性显著相关。建议对结核病治疗患者进行物质使用的常规筛查和治疗，并持续监测药物治疗依从性。
