Institute of Microelectronics of the Chinese Academy of Sciences, Beijing 100029, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
Biosensors (Basel). 2024 Jan 12;14(1):0. doi: 10.3390/bios14010039.
Chiral sensing is crucial in the fields of biology and the pharmaceutical industry. Many naturally occurring biomolecules, i.e., amino acids, sugars, and nucleotides, are inherently chiral. Their enantiomers are strongly associated with the pharmacological effects of chiral drugs. Owing to the extremely weak chiral light-matter interactions, chiral sensing at an optical frequency is challenging, especially when trace amounts of molecules are involved. The nanophotonic platform allows for a stronger interaction between the chiral molecules and light to enhance chiral sensing. Here, we review the recent progress in nanophotonic-enhanced chiral sensing, with a focus on the superchiral near-field and enhanced circular dichroism (CD) spectroscopy generated in both the dielectric and in plasmonic structures. In addition, the recent applications of chiral sensing in biomedical fields are discussed, including the detection and treatment of difficult diseases, i.e., Alzheimer's disease, diabetes, and cancer.
手性传感在生物学和制药行业中至关重要。许多天然存在的生物分子,如氨基酸、糖和核苷酸,本质上是手性的。它们的对映异构体与手性药物的药理作用密切相关。由于手性光物质相互作用非常微弱,因此在光学频率下进行手性传感具有挑战性,特别是当涉及痕量分子时。纳米光子平台允许手性分子与光之间进行更强的相互作用,从而增强手性传感。在这里,我们综述了纳米光子增强手性传感的最新进展,重点介绍了在介电和等离子体结构中产生的超手性近场和增强圆二色性(CD)光谱。此外,还讨论了手性传感在生物医学领域的最新应用,包括对阿尔茨海默病、糖尿病和癌症等难治性疾病的检测和治疗。