Yavuzcan Ali, Yurtçu Engin, Keyif Betül, Osmanlıoğlu Şeyma
Department of Obstetrics and Gynecology, Sağlık Bilimleri University, Ankara 06010, Türkiye.
Department of Obstetrics and Gynecology, Düzce University, Düzce 81620, Türkiye.
J Pers Med. 2023 Dec 28;14(1):43. doi: 10.3390/jpm14010043.
(1) Background: We aimed to investigate the effect of change in pre-wash and post-wash semen parameters on intrauterine insemination (IUI) success in a homogenous study group. (2) Methods: IUI cycles conducted at an infertility clinic were included in this study. Patient records were examined retrospectively. Δ sperm count (per mL) was calculated as [pre-wash sperm count (per mL)-post-wash sperm count (per mL)]. Δ Total progressive motile sperm count (TPMSC) was also calculated as (post-wash TPMSC-pre-wash TPMSC). (3) Results: No statistically significant difference was detected in terms of Δ sperm count ( = 0.38), and Δ TPMSC ( = 0.76) regarding the clinical pregnancy rate (CPR). There was no statistically significant difference between CPR (+) and CPR (-) groups in terms of post-wash sperm count, TPMSC, TPMSC ≥ 10 × 10⁶, TPMSC ≥ 5 × 10⁶ ( = 0.65, = 0.79, = 0.49, = 0.49, respectively). The live birth rate (LBR) showed no statistically significant differences except for a pre-wash TPMSC ≥ 10 × 10⁶ ( = 0.02). Through the performed ROC analysis, no statistically significant cutoff value could be set for the pre-wash TPMSC. (4) Conclusions: There is only a pre-wash TPMSC ≥ 10 × 10⁶ that showed a significant role in the success of IUI, even when considering all other pre-wash and post-wash semen parameters. Δ sperm count and Δ are not useful markers for IUI success.
(1) 背景：我们旨在研究在一个同质研究组中，洗前和洗后精液参数的变化对宫腔内人工授精（IUI）成功率的影响。(2) 方法：本研究纳入了一家不孕不育诊所进行的IUI周期。对患者记录进行回顾性检查。Δ精子计数（每毫升）计算为[洗前精子计数（每毫升）-洗后精子计数（每毫升）]。Δ总前向运动精子计数（TPMSC）也计算为（洗后TPMSC - 洗前TPMSC）。(3) 结果：在临床妊娠率（CPR）方面，Δ精子计数（P = 0.38）和Δ TPMSC（P = 0.76）未检测到统计学上的显著差异。CPR（+）组和CPR（-）组在洗后精子计数、TPMSC、TPMSC≥10×10⁶、TPMSC≥5×10⁶方面无统计学显著差异（分别为P = 0.65、P = 0.79、P = 0.49、P = 0.49）。除了洗前TPMSC≥10×10⁶外，活产率（LBR）未显示出统计学上的显著差异（P = 0.02）。通过进行的ROC分析，无法为洗前TPMSC设定统计学上的显著临界值。(4) 结论：即使考虑所有其他洗前和洗后精液参数，只有洗前TPMSC≥10×10⁶在IUI成功中显示出显著作用。Δ精子计数和Δ不是IUI成功的有用标志物。
