Al Bshabshe Ali, Alqahtani Mushary, Amer Khaled A, Al-Jahash Najla A, Thwab Abduallh S, Alshahrani Faleh S, Saad Aldarani Alshahrani Abdullah, Asiri Osama A, Abughazalah Faisal N, Khuzayyim Ahmed Ali A, Altumaihi Faisal, Khawaji Turki, Algaide Ayman, Almontasheri Moyed
Critical Care, King Khalid University, Abha, SAU.
Internal Medicine, Armed Forces Hospitals Southern Region, Khamis Mushait, SAU.
Cureus. 2023 Dec 22;15(12):e50935. doi: 10.7759/cureus.50935. eCollection 2023 Dec.
Introduction The global COVID-19 pandemic has triggered an unprecedented public health crisis, emphasizing the need to understand factors influencing disease outcomes. This study explores the role of genetic variations in blood group antigens, particularly ABO and RhD, in shaping mortality rates among critically ill COVID-19 patients in the southern region of Saudi Arabia. Methods Utilizing a retrospective, noninterventional approach, we analyzed medical records of 594 COVID-19 patients admitted to the intensive care unit (ICU) at Aseer Central Hospital from August 2020 to April 2021. The cohort, with a mean age of 60.5 years, consisted of a predominantly male population. Results The study encompassed a diverse age range of 18 to 103 years, with a mean age of 60.5 ± 17.3 years. Of the 594 patients, 398 (67%) were male, and only 5 (0.8%) had a history of smoking. Blood group distribution revealed 275 (48.4%) with O-, 189 (33.3%) with A+, and 51 (9%) with AB- types. Predominant chronic conditions included diabetes mellitus (35.5%). Tragically, 320 patients (54.6%) experienced mortality, with a 100% mortality rate for the B+ blood group and 92.9% for O- blood group. Conclusion This analysis establishes significant statistical links, underscoring the pivotal role of blood type, particularly the Rh factor, in influencing mortality risk among critically ill COVID-19 patients. These findings contribute valuable insights into risk stratification and personalized care for severe cases, emphasizing the importance of genetic considerations in understanding disease outcomes.
引言 全球新冠疫情引发了一场前所未有的公共卫生危机，凸显了了解影响疾病转归因素的必要性。本研究探讨血型抗原，特别是ABO和RhD基因变异在沙特阿拉伯南部地区重症新冠患者死亡率形成中的作用。方法 采用回顾性、非干预性方法，我们分析了2020年8月至2021年4月在阿西尔中心医院重症监护病房（ICU）收治的594例新冠患者的病历。该队列平均年龄为60.5岁，主要为男性人群。结果 该研究涵盖了18至103岁的不同年龄范围，平均年龄为60.5±17.3岁。在594例患者中，398例（67%）为男性，只有5例（0.8%）有吸烟史。血型分布显示，O-型血275例（48.4%），A+型血189例（33.3%），AB-型血51例（9%）。主要慢性病包括糖尿病（35.5%）。不幸的是，320例患者（54.6%）死亡，B+血型死亡率为100%，O-血型死亡率为92.9%。结论 本分析建立了显著的统计学关联，强调血型，特别是Rh因子在影响重症新冠患者死亡风险中的关键作用。这些发现为重症病例的风险分层和个性化护理提供了有价值的见解，强调了基因因素在理解疾病转归中的重要性。
